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A Phase 2 Randomised Clinical Trial Assessing the Tolerability of Two...
“Background: Cannabis for cancer is very topical and, given the use of illicit cannabis preparations used in this vulnerable population, research investigating standardised, quality-assured medicinal...
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Effects of tetrahydrocannabinols on human oral cancer cell proliferation,...
“Cannabinoids, including delta-8- and delta-9-tetrahydrocannabinol (THC) have a palliative care impact and may therefore be beneficial against cancer. The aim of this study was to investigate the...
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The Interplay between the Immune and the Endocannabinoid Systems in Cancer
“The therapeutic potential of Cannabis sativa has been recognized since ancient times. Phytocannabinoids, endocannabinoids and synthetic cannabinoids activate two major G protein-coupled receptors,...
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Cancer Initiation, Progression and Resistance: Are Phytocannabinoids from...
“Cannabis sativa L. is a source of over 150 active compounds known as phytocannabinoids that are receiving renewed interest due to their diverse pharmacologic activities. Indeed, phytocannabinoids...
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New Insights on Hemp Oil Enriched in Cannabidiol: Decarboxylation,...
“This study aimed to obtain and characterize extracted hemp oil enriched in cannabidiol (CBD) by decarboxylation of cannabidiolic acid (CBDA) and to give new insights into its antioxidant and...
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Cannabinoids in the landscape of cancer
“Cannabinoids are a group of terpenophenolic compounds derived from the Cannabis sativa L. plant. There is a growing body of evidence from cell culture and animal studies in support of cannabinoids...
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Medical marijuana utilization in gynecologic cancer patients
“Medical marijuana (MM) use is common among cancer patients, but relatively little is known about the usage patterns and efficacy of MM used by gynecologic cancer patients. Methods: Demographic and...
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Pros and Cons of the Cannabinoid System in Cancer: Focus on Hematological...
“The endocannabinoid system (ECS) is a composite cell-signaling system that allows endogenous cannabinoid ligands to control cell functions through the interaction with cannabinoid receptors....
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Cannabinoids and their derivatives in struggle against melanoma
“Melanoma is one of the most aggressive malignances in human. Recently developed therapies improved overall survival rate, however, the treatment of melanoma still remains a challenging issue. This...
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Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory...
“In humans, various sites like cannabinoid receptors (CBR) having a binding affinity with cannabinoids are distributed on the surface of different cell types, where endocannabinoids (ECs) and...
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Searching for a New Anti-Cancer Drug: Investigation of KY Hemp-Induced...
“Marijuana (cannabis sativa) is a schedule 1 drug that has been recently approved by some states in the US for its therapeutic benefit. Although there are a few reports about its anti-cancer...
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KY Hemp-induced Modulation of Ovarian Cancer Cell Metastasis
“Our laboratory is interested in searching for a new plant-based therapeutics to treat ovarian cancer. We are interested in studying anti-cancer effects of KY grown hemp as a potential candidate drug....
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Cannabidiol Loaded Extracellular Vesicles Sensitize Triple-Negative Breast...
“Extracellular Vesicles (EVs) were isolated from human umbilical cord mesenchymal stem cells (hUCMSCs) and were further encapsulated with cannabidiol (CBD) through sonication method (CBD EVs). CBD EVs...
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The Pharmacological Effects of Plant-Derived versus Synthetic Cannabidiol in...
“Introduction: Cannabidiol (CBD) can be isolated from Cannabis sativa L. or synthetically produced. The aim of this study was to compare the in vitro effects of purified natural and synthetic CBD to...
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Combination therapy with cannabidiol and chemotherapeutics in canine...
“Background: Canine urothelial carcinoma is the most common form of canine bladder cancer. Treatment with chemotherapy has variable response rates leading to most dogs succumbing to their disease...
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A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by...
“Cannabidiol (CBD), a phytochemical derived from Cannabis sativa L., has been demonstrated to exhibit promising anti-tumor properties in multiple cancer types. However, the effects of CBD on...
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Association Between Smoking Cannabis and Quitting Cigarettes in a Large...
“Background: Cannabis use is increasing, including among smokers, an at-risk population for cancer. Research is equivocal on whether using cannabis inhibits quitting cigarettes. The current...
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α-Pinene: A never-ending story
“α-Pinene represents a member of the monoterpene class and is highly distributed in higher plants like conifers, Juniper ssp. and Cannabis ssp. α-Pinene has been used to treat respiratory tract...
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The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate...
“Prostate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In...
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Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human...
“Cannabidiol (CBD), the major non-psychoactive compound found in cannabis, is frequently used both as a nutraceutical and therapeutic. Despite anecdotal evidence as an anticancer agent, little is...
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