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α-Pinene: A never-ending story

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Phytochemistry“α-Pinene represents a member of the monoterpene class and is highly distributed in higher plants like conifers, Juniper ssp. and Cannabis ssp.

α-Pinene has been used to treat respiratory tract infections for centuries. Furthermore, it plays a crucial role in the fragrance and flavor industry. In vitro assays have shown an enantioselective profile of (+)- and (-)-α-pinene for antibacterial and insecticidal activity, respectively.”

https://pubmed.ncbi.nlm.nih.gov/34365295/

https://www.sciencedirect.com/science/article/pii/S0031942221002065?via%3Dihub

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“α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway. Our findings demonstrate that α-pinene activates NK cells and increases NK cell cytotoxicity, suggesting it is a potential compound for cancer immunotherapy.” https://pubmed.ncbi.nlm.nih.gov/33440866/

“α-Pinene inhibits tumor invasion through downregulation of nuclear factor (NF)-κB-regulated matrix metalloproteinase-9 gene expression in MDA-MB-231 human breast cancer cells. These results suggest that α-pinene has a significant effect on the inhibition of tumor invasion and may potentially be developed into an anti-metastatic drug.”   https://applbiolchem.springeropen.com/articles/10.1007/s13765-016-0175-6

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