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The Endocannabinoid System: A Potential Target for the Treatment of Various...
“The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a balance in internal environment (temperature, mood, and immune system) and energy input and output in living,...
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The antitumor activity of cannabidiol on lung cancer cell lines A549 and...
“In the recent years, the application of new antitumor drugs has focused on the replacement of conventional chemotherapeutics with compounds derived from natural products. Cannabidiol (CBD) is one of...
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Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation...
“Despite the multiple preventive measures and treatment options, colorectal cancer holds a significant place in the world’s disease and mortality rates. The development of novel therapy is in critical...
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Cannabinoids and Cancer
“Cannabinoids, active components of the plant Cannabis sativa, had been used for centuries in ancient medicine as therapeutic remedies for a variety of conditions, before becoming stigmatized due to...
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Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the...
“Cannabidiol (CBD), a primary bioactive phytocannabinoid extracted from hemp, is reported to possess potent anti-tumorigenic activity in multiple cancers. However, the effects of CBD on bladder cancer...
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The strengths and limits of cannabinoids and their receptors in cancer:...
“Cancer, as a mysterious and complex disease, has a multi-stage molecular process that uses the cellular molecular machine and multiple signaling pathways to its advantage. Cannabinoids, as...
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Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71...
“Aims: Characterizing cannabinoid receptors (CBRs) expressed in Ewing sarcoma (EWS) cell lines as potential targets for anti-cancer drug development. Main methods: CBR affinity and function were...
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Lung cancer patient who had declined conventional cancer treatment: could the...
“Conventional lung cancer treatments include surgery, chemotherapy and radiotherapy; however, these treatments are often poorly tolerated by patients. Cannabinoids have been studied for use as a...
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β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal...
“Beta-Caryophyllene (BCP), a naturally occurring sesquiterpene abundantly found in cloves, hops, and cannabis, is the active candidate of a relatively new group of vascular-inhibiting compounds that...
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Perspectives of pediatric oncologists and palliative care physicians on the...
“Background: Children with cancer are increasingly using cannabis therapeutically. Aim: The purpose of this study was to determine the perspectives and practices of pediatric oncologists and palliative...
View ArticleInhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of...
“Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) and its interaction with...
View ArticleCannabidiol Suppresses Angiogenesis and Stemness of Breast Cancer Cells by...
“To assess the effect of Cannabidiol (CBD) on the angiogenesis and stemness of breast cancer cells as well as proliferation. Methods: mRNA level and the amount of protein of vascular endothelial...
View ArticleCannabidiol Inhibits Tumorigenesis in Cisplatin-Resistant Non-Small Cell Lung...
“Chemotherapy forms the backbone of current treatments for many patients with advanced non-small-cell lung cancer (NSCLC). However, the survival rate is low in these patients due to the development of...
View ArticleCannabidiol promotes apoptosis of osteosarcoma cells in vitro and in vivo by...
“Osteosarcoma is the most common primary malignant bone tumor that often occurs in children, adolescents, and young adults. Cannabidiol plays an essential role in cancer treatment. However, its...
View ArticleEndocannabinoid signaling in glioma
“High-grade gliomas constitute the most frequent and aggressive form of primary brain cancer in adults. These tumors express cannabinoid CB1 and CB2 receptors, as well as other elements of the...
View ArticleTargeting the Endocannabinoidome in Pancreatic Cancer
“Pancreatic Ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, is an aggressive and lethal form of cancer with a very high mortality rate. High heterogeneity, asymptomatic...
View ArticleTargeting the Endocannabinoid System: From the Need for New Therapies to the...
“Pancreatic cancer is one of the most fatal malignancies, and therefore, new strategies, which aim at the improvement of the prognosis of this lethal disease, are needed. Many clinical trials have...
View ArticleCannabis sativa Extract Induces Apoptosis in Human Pancreatic 3D Cancer...
“In recent years, interest in Cannabis sativa L. has been rising, as legislation is moving in the right direction. This plant has been known and used for thousands of years for its many active...
View ArticleCannabis as a potential compound against various malignancies, legal aspects,...
“Various preclinical and clinical studies exhibited the potential of cannabis against various diseases, including cancer and related pain. Subsequently, many efforts have been made to establish and...
View ArticleCannabidiol and Other Phytocannabinoids as Cancer Therapeutics
“Preclinical models provided ample evidence that cannabinoids are cytotoxic against cancer cells. Among the best studied phytocannabinoids, cannabidiol (CBD) is most promising for the treatment of...
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