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Cancer is a Preventable Disease that Requires Major Lifestyle Changes
“This year, more than 1 million Americans and more than 10 million people worldwide are expected to be diagnosed with cancer, a disease commonly believed to be preventable. Only 5–10% of all cancer...
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Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and...
“Cervical cancer remains a global health related issue among females of Sub-Saharan Africa, with over half a million new cases reported each year. Different therapeutic regimens have been suggested in...
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Spontaneous Cannabinoid Receptor 2 (CB2) Expression in the Cochlea of Adult...
“We provide evidence for the presence of cannabinoid CB2 receptors in some cellular types of the cochlea of the adult albino rat. Cannabinoids and their receptors are increasingly being studied...
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Spontaneous involution of pediatric low-grade gliomas: high expression of...
“Pediatric low-grade gliomas (P-LGG) consist of a mixed group of brain tumors that correspond to the majority of CNS tumors in children. Notably, they may exhibit spontaneous involution after subtotal...
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Evaluation of Two Commercially Available Cannabidiol Formulations for Use in...
“Since 24 states and the District of Columbia have legalized marijuana in some form, suppliers of legal marijuana have developed Cannabis sativa products for use in electronic cigarettes...
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Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents...
“The term “cannabinoids” designates a family of compounds with activity upon cannabinoid receptors. Cannabinoids are classified in three groups: phytocannabinoids, endocannabinoids, and the synthetic...
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Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via...
“Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely...
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Comparing the effects of endogenous and synthetic cannabinoid receptor...
“Anti-neoplastic activity induced by cannabinoids has been extensively documented for a number of cancer cell types; however, this topic has been explored in gastric cancer cells only in a limited...
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May cannabinoids prevent the development of chemotherapy-induced diarrhea and...
“The antineoplastic drug 5-fluoruracil (5-FU) is a pirimidine analog, which frequently induces potentially fatal diarrhea and mucositis. Cannabinoids reduce gastrointestinal motility and secretion and...
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β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and...
“Natural bicyclic sesquiterpenes, β-caryophyllene (BCP) and β-caryophyllene oxide (BCPO), are present in a large number of plants worldwide. Both BCP and BCPO (BCP(O)) possess significant anticancer...
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Dendritic Cell Regulation by Cannabinoid-Based Drugs.
“Cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models and in humans have produced promising results using...
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Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against...
“Chemotherapy-induced nausea and vomiting (CINV) is a complex pathophysiological condition and consists of two phases. The conventional CINV neurotransmitter hypothesis suggests that the immediate...
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Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix...
“Cannabinoids, the active components of Cannabis sativa L. and their derivatives, inhibit tumor growth in laboratory animals by inducing apoptosis of tumor cells and impairing tumor angiogenesis. It...
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Overexpression of cannabinoid receptor 1 promotes renal cell carcinoma...
“Renal cell carcinoma (RCC) is a common urologic tumor with a poor prognosis. Cannabinoid receptor 1 (CB1), which is a G protein-coupled receptor, has recently been reported to participate in the...
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Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells...
“Several studies showed a potential anti-tumor role for cannabinoids, by modulating cell signaling pathways involved in cancer cell proliferation, chemo-resistance and migration. Cannabidiol (CBD) was...
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The effects of cannabidiol and its synergism with bortezomib in multiple...
“Multiple myeloma (MM) is a plasma cell (PC) malignancy characterised by the accumulation of a monoclonal PC population in the bone marrow (BM). Cannabidiol (CBD) is a non-psychoactive cannabinoid...
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Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the...
“Cannabinoid receptor-2 (CB2) is expressed dominantly in the immune system, especially on plasma cells. Cannabinergic ligands with CB2 selectivity emerge as a class of promising agents to treat...
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Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents.
“Cancer is the second leading cause of death in the United States with 1.7 million new cases estimated to be diagnosed in 2016. This disease remains a formidable clinical challenge and represents a...
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Cannabinoid derivatives exert a potent anti-myeloma activity both in vitro...
“Although hematopoietic and immune system show high levels of the cannabinoid receptor CB2, the potential effect of cannabinoids on hematologic malignancies has been poorly determined. Here we have...
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WIN 55,212-2 Inhibits the Epithelial Mesenchymal Transition of Gastric Cancer...
“Cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to reports that they can affect the tumor growth, migration, and metastasis....
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