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Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.
“Modulation of the CB2 receptor is an interesting approach for pain and inflammation, arthritis, addictions, neuroprotection, and cancer, among other possible therapeutic applications, and is devoid of...
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The Use of Medical Marijuana in Cancer.
“The use of medical marijuana in cancer care presents a dilemma for both patients and physicians. The scientific evidence is evolving, yet much of the known information is still insufficient to...
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Endocannabinoid system: a promising therapeutic target for the treatment of...
“The therapeutic properties of cannabinoids are well-known since ancient years. Growing evidence exist on endocannabinoid system (ECS) modulation related with human tumorigenesis. Taking into account...
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Phytochemicals as adjunctive with conventional anticancer therapies.
“Cancer is defined as the abnormal proliferations of cells which could occur in any tissue and can cause life-threatening malignancies with high financial costs for both patients and health care...
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Inhibition of human tumour prostate PC-3 cell growth by cannabinoids...
“We have previously shown that cannabinoids induce growth inhibition and apoptosis in prostate cancer PC-3 cells, which express high levels of cannabinoid receptor types 1 and 2 (CB1 and CB2). In this...
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CANNABIS CHEMICALS STOP PROSTATE CANCER GROWTH
“ACTIVE chemicals in cannabis have been shown to halt prostate cancer cell growth according to research published in the British Journal of Cancer*. Researchers from the University of Alcala, in Madrid...
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The cannabinoid WIN 55,212-2 prevents neuroendocrine differentiation of LNCaP...
“Neuroendocrine (NE) differentiation represents a common feature of prostate cancer and is associated with accelerated disease progression and poor clinical outcome. Nowadays, there is no treatment for...
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Cannabimimetic Drugs: Recent Patents in Central Nervous System Disorders.
“Agents acting via cannabinoid receptors have been widely developed; starting from the chemical structure of phytocannabinoids isolated from cannabis sativa plant, specific and selective compounds of...
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Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes...
“The orphan G protein-coupled receptor GPR55 has been directly or indirectly related to basic alterations that drive malignant growth: uncontrolled cancer cell proliferation, sustained angiogenesis,...
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Cannabinoid signalling in glioma cells
“Cannabinoids, originally derived from Cannabis sativa, as well as their endogenous and synthetic counterparts, were shown to induce apoptosis of glioma cells in vitro and tumour regression in vivo via...
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Anticancer and antioxidant properties of terpinolene in rat brain cells.
“Terpinolene (TPO) is a natural monoterpene present in essential oils of many aromatic plant species. Our findings clearly demonstrate that TPO is a potent antiproliferative agent for brain tumour...
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Cannabinoids for Symptom Management and Cancer Therapy: The Evidence.
“Cannabinoids bind not only to classical receptors (CB1 and CB2) but also to certain orphan receptors (GPR55 and GPR119), ion channels (transient receptor potential vanilloid), and peroxisome...
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5-lipoxygenase mediates docosahexaenoyl ethanolamide and...
“Endocannabinoids have recently drawn attention as promising anti-cancer agents. We previously observed that anandamide (AEA), one of the representative endocannabinoids, effectively inhibited the...
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Endocannabinoid system as a regulator of tumor cell malignancy – biological...
“The endocannabinoid system (ECS) comprises cannabinoid receptors (CBs), endogenous cannabinoids, and enzymes responsible for their synthesis, transport, and degradation of (endo)cannabinoids. To...
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In vitro and in vivo evaluation of Δ⁹-tetrahidrocannabinol/PLGA nanoparticles...
“Nanoplatforms can optimize the efficacy and safety of chemotherapy, and thus cancer therapy. However, new approaches are encouraged in developing new nanomedicines against malignant cells. In this...
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Preparation and characterization of Δ(9)-tetrahydrocannabinol-loaded...
“Cannabinoids present an interesting therapeutic potential as antiemetics, appetite stimulants in debilitating diseases (cancer, AIDS and multiple sclerosis), analgesics, and in the treatment of...
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Endocannabinoid system as a regulator of tumor cell malignancy – biological...
“The endocannabinoid system (ECS) comprises cannabinoid receptors (CBs), endogenous cannabinoids, and enzymes responsible for their synthesis, transport, and degradation of (endo)cannabinoids. To...
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Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein...
“This study has implications for developing new therapeutics for the treatment of cancer, pain, and metabolic disorders. GPR55 is activated by l-α-lysophosphatidylinositol (LPI) but also by certain...
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Inhibition of interleukin-8 release in the human colonic epithelial cell line...
“We have investigated the effects of cannabinoid agonists and antagonists on tumour necrosis factor-alpha (TNF-alpha)-induced secretion of interleukin-8 from the colonic epithelial cell line, HT-29....
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Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and...
“Despite the advent of classic anti-emetics, chemotherapy-induced nausea is still problematic, with vomiting being somewhat better managed in the clinic. If post-treatment nausea and vomiting are not...
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