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Clinical trials of medicinal cannabis for appetite-related symptoms from...
“Australian clinical trials are planned to evaluate medicinal cannabis in a range of clinical contexts. To explore the preferences, attitudes and beliefs of patients eligible and willing to consider...
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Quantitative analyses of synergistic responses between cannabidiol and...
“Evidence suggests that the non-psychotropic cannabis-derived compound, cannabidiol (CBD), has anti-neoplastic activity in multiple types of cancers, including glioblastoma multiforme (GBM)....
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Bioactive spirans and other constituents from the leaves of Cannabis sativa...
“In this paper, 17 compounds (1-17) were isolated from the leaves of Hemp (Cannabis sativa f. sativa). Among the isolates, two were determined to be new spirans: cannabispirketal (1), and...
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A Science Based Evaluation of Cannabis and Cancer
“The irritant properties of all smoke will naturally tend to promote a pro-inflammatory immune response with the corresponding production of potentially carcinogenic free radicals. However, cannabis...
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State of the evidence: Cannabinoids and cancer pain-A systematic review.
“Cannabinoids are widely used to alleviate intractable symptoms such as pain, nausea, and muscle spasticity. The purpose of this review was to ascertain the current state of the science regarding use...
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Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at...
“Tamoxifen (Tam) is a selective estrogen receptor (ER) modulator (SERM) that is an essential drug to treat ER-positive breast cancer. Aside from known actions at ERs, recent studies have suggested...
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Dronabinol treatment of delayed chemotherapy-induced nausea and vomiting (CINV).
“Dronabinol (MARINOL), synthetic tetrahydrocannabinol, binds to cannabinoid receptors and has antiemetic activity. To explore if this novel mechanism would be of benefit in delayed CINV, dronabinol...
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Tolerability of dronabinol alone, ondansetron alone and the combination of...
“Dronabinol (Marinol), the synthetic version of tetrahydrocannabinol, is used to treat nausea and vomiting following cancer chemotherapy (CINV). It has a unique mechanism of action (cannabinoid...
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The use of cannabinoids (CBs) for the treatment of chemotherapy-induced...
“CIPN is a common toxicity associated with the use of chemotherapy (CT) agents such as platinums, taxanes and vinca alkaloids. Patients (pts) may suffer from pain that adversely affects their quality...
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Inhibition of cervical cancer cell proliferation by cannabidiol
“Seventy phytocannabinoids are now known to be synthesized by Cannabis sativa (marijuana)]. The major non-psychoactive cannabinoid cannabidiol (CBD) exhibits antiproliferative effects against breast,...
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Dietary olive oil induces cannabinoid CB2 receptor expression in adipose...
“Cannabinoid– 2 (CB2) receptor is known for its anti-obesity effects silencing the activated immune cells that are key drivers of metabolic syndrome and inflammation. Nutritional interventions in...
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Extravirgin olive oil up-regulates CB₁ tumor suppressor gene in human colon...
“Extravirgin olive oil (EVOO) represents the typical lipid source of the Mediterranean diet, an eating habit pattern that has been associated with a significant reduction of cancer risk. Diet is the...
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Medical Cannabis in the Palliation of Malignant Wounds—A Case Report
“Anecdotal accounts of the use of topical extracts from the cannabis plant being used on open wounds date back to antiquity. In modern times, cannabinoid therapies have demonstrated efficacy as...
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Experts’ Perspectives on the Role of Medical Marijuana in Oncology: a...
“Expansion of medical marijuana (MM) laws in the United States may offer oncology new therapeutic options. This study qualitatively explored professional opinion around the role of MM in cancer care....
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A user’s guide to cannabinoid therapies in oncology.
“”Cannabinoid” is the collective term for a group of chemical compounds that either are derived from the Cannabis plant, are synthetic analogues, or occur endogenously. Although cannabinoids interact...
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Therapeutic potential of cannabinoids in counteracting chemotherapy-induced...
“Cannabinoids (the active constituents of Cannabis sativa) and their derivatives have got intense attention during recent years because of their extensive pharmacological properties. Cannabinoids...
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Cannabinoids – a new weapon against cancer?
“Cannabis has been cultivated by man since Neolithic times. It was used, among others for fiber and rope production, recreational purposes and as an excellent therapeutic agent. The isolation and...
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Tumor-promoting effects of cannabinoid receptor type 1 in human melanoma cells.
“The role of endocannabinoid system in melanoma development and progression is actually not fully understood. This study was aimed at clarifying whether cannabinoid-type 1 (CB1) receptor may function...
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Use of medical cannabis to reduce pain and improve quality of life in cancer...
“Early attention to pain and symptoms in those with cancer improves both quality of life and survival. Opioid medications are the mainstay treatment of cancer-related pain. Cannabinoids are...
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Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal...
“Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. In this study we aimed to investigate the...
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