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Cannabinoids: Medical implications.
“Herbal cannabis has been used for thousands of years for medical purposes. With elucidation of the chemical structures of tetrahydrocannabinol (THC) and cannabidiol (CBD) and with discovery of the...
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Medical Marijuana Use in Oncology: A Review.
“Medicinal marijuana use is currently legal in 23 states and the District of Columbia. As more states approve marijuana use for medical indications, physicians will be asked by their patients for more...
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Medical marijuana use in head and neck squamous cell carcinoma patients...
“The purpose of the study was to better understand why patients with history of head and neck cancer (HNC) treated with radiotherapy are using medical marijuana (MM). RESULTS: There was a 100 %...
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Techniques and technologies for the bioanalysis of Sativex®, metabolites and...
“Sativex® is an oromucosal spray indicated for the treatment of moderate-to-severe spasticity in multiple sclerosis and is also an effective analgesic for advanced cancer patients. Sativex contains...
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In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma.
“Neuroblastoma (nbl) is one of the most common solid cancers in children. Prognosis in advanced nbl is still poor despite aggressive multimodality therapy. Furthermore, survivors experience severe...
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Use of cannabinoids in cancer care: palliative care
“Cannabinoid Integrative Medicine In Oncologic Palliative Care. The opportunities to improve and expand palliative care are many. In this supplement, Current Oncology is presenting a discussion on...
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Integrating cannabis into clinical cancer care.
“Cannabis species have been used as medicine for thousands of years; only since the 1940s has the plant not been widely available for medical use. However, an increasing number of jurisdictions are...
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Anticancer mechanisms of cannabinoids.
“In addition to the well-known palliative effects of cannabinoids on some cancer-associated symptoms, a large body of evidence shows that these molecules can decrease tumour growth in animal models of...
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Cannabis and cancer: toward a new understanding
“The treatment of cancer, including the disease itself and the symptoms associated with cancer and its therapy, is one of the most important emerging frontiers in cannabinoid therapeutics. This...
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Antitumorigenic targets of cannabinoids – current status and implications.
“Molecular structures of the endocannabinoid system have gained interest as potential pharmacotherapeutical targets for systemic cancer treatment. The present review covers the contribution of the...
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Suppression of invasion and metastasis in aggressive salivary cancer cells...
“Salivary gland cancer (SGC) represents the most common malignancy in the head and neck region, and often metastasizes to the lungs. The helix-loop-helix ID1 protein has been shown to control...
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ENDOCANNABINOID SYSTEM: A multi-facet therapeutic target.
“Cannabis sativa is also popularly known as marijuana. It is being cultivated and used by man for recreational and medicinal purposes from many centuries. Study of cannabinoids was at bay for very...
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New review sheds light on cannabinoids anticancer mechanisms
“The palliative effects of cannabinoids on cancer-related symptoms are well established. In fact, many drugs comprised of delta-9-tetrahydrocannabinol (THC) or its synthetic analogues are currently...
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Study: Cannabinoids Limit Neuroblastoma Cell Proliferation
“The administration of the cannabinoids THC and CBD limit cancer activity in neuroblastoma cells in culture and in animals, according to preclinical data published in the journal Current Oncology....
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The Influence of Biomechanical Properties and Cannabinoids on Tumor Invasion.
“Cannabinoids are known to have an anti-tumorous effect, but the underlying mechanisms are only sparsely understood. Mechanical characteristics of tumor cells represent a promising marker to...
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Phytocannabinoids and cannabimimetic drugs: recent patents in central nervous...
“Starting from the chemical structure of phytocannabinoids, isolated from Cannabis sativa plant, research groups designed numerous cannabimimetic drugs. These compounds according to their activities...
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Modulation of breast cancer cell viability by a cannabinoid receptor 2...
“Breast cancer is the leading cause of cancer-related deaths among women aged 34–50 worldwide, and is the most commonly diagnosed metastasizing tumor in women of all ages. Despite advances in...
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Difference and Influence of Inactive and Active States of Cannabinoid...
“Cannabinoid receptor 2 (CB2), a G protein-coupled receptor (GPCR), is a promising target for the treatment of neuropathic pain, osteoporosis, immune system, cancer, and drug abuse.”...
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Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR...
“Breast cancer is the second leading cause of cancer deaths among women. Cannabinoid receptor 2 (CNR2 or CB2) is an integral part of the endocannabinoid system. Although CNR2 is highly expressed in...
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Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Cisplatin-Induced...
“Sativex, a cannabinoid extract with a 1 : 1 ratio of tetrahydocannabinol and cannabidiol, has been shown to alleviate neuropathic pain associated with chemotherapy. This research examined whether...
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