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From bench to bedside: the application of cannabidiol in glioma
“Glioma is the most common malignant tumor in central nervous system, with significant health burdens to patients. Due to the intrinsic characteristics of glioma and the lack of breakthroughs in...
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NHS-Reimbursed Cannabis Flowers for Cancer Palliative Care and the Management...
“Chemotherapy-induced nausea and vomiting (CINV) is a debilitating side effect of cancer treatment, affecting many patients. Cannabinoid agonists, such as nabilone and Δ9-tetrahydrocannabinol (THC),...
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Canniprene B, a new prenylated dihydrostilbene with cytotoxic activities from...
“A new, canniprene B (4), along with five known (1–3 and 5–6) dihydrostilbenes were isolated from the leaves of Cannabis sativa collected at CSIR – IIIM, Jammu, India. Structures of all isolated...
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Synthesis and antiproliferative activity of CBD aromatic ester derivatives
“This study involved the synthesis of a series of novel cannabidiol (CBD) aromatic ester derivatives, including CBD-8,12-diaromaticester derivatives (compounds 2a-2t) and...
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Topical Nanoencapsulated Cannabidiol Cream as an Innovative Strategy...
“Background: Ultraviolet-A radiation (UVA) contributes to photoaging/photocarcinogenesis by generating inflammation and oxidative damage. Current photoprotective strategies are limited by...
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Melanoma and cannabinoids: A possible chance for cancer treatment
“The endocannabinoid system is composed by a complex and ubiquitous network of endogenous lipid ligands, enzymes for their synthesis and degradation, and receptors, which can also be stimulated by...
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Integrated metabolomics and proteomics analyses to reveal anticancer...
“Cannabis sativa L., with a rich history in Chinese folk medicine, includes hemp strains that offer substantial economic and medical benefits due to their non-addictive properties. Hemp has...
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Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota...
“Chemotherapy-induced peripheral neuropathy (CIPN) remains a clinical challenge for up to 80% of breast cancer survivors. In an open-label study, participants underwent three interventions: standard...
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Combinatorial approach of cannabidiol and active-targeted-mediated...
“Malignant melanoma (MM) continues to claim millions of lives around the world due to its limited therapeutic alternatives. Photodynamic therapy (PDT) has gained popularity in cancer treatment due it...
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In Silico Approach for Assessment of the Anti-tumor Potential of Cannabinoid...
“Glucose-6-phosphate dehydrogenase (G6PD) is a pentose phosphate pathway (PPP) enzyme that generates NADPH, which is required for cellular redox equilibrium and reductive biosynthesis. It has been...
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Comparative Analysis of Polyphenolic Profile and Chemopreventive Potential of...
“This study investigates the phytochemical composition and biological activities of hemp (Cannabis sativa L.) leaves, flowers’ methanolic extracts from the Sofia variety, and its sprouts cultivated...
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Medical Cannabis Prescription Practices and Quality of Life in Thai Patients:...
“Introduction: The legalization of cannabis in Thailand has renewed interest in its traditional medical use. This study aimed to explore the prescribing patterns of traditional practitioners and...
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Oral Cannabis Extract for Secondary Prevention of Chemotherapy-Induced Nausea...
“Purpose: The aim of this randomized, placebo-controlled, two-stage, phase II/III trial was to determine the efficacy of an oral cannabis extract in adults with refractory nausea and/or vomiting...
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Cannabidiol Enhances the Anticancer Activity of Etoposide on Prostate Cancer...
“Introduction: Cannabis sativa extract has been used as an herbal medicine since ancient times. It is one of the most researched extracts, especially among supportive treatments against cancer....
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Cannabis for Refractory Chemotherapy-Induced Nausea and Vomiting
“Chemotherapy-induced nausea and vomiting (CINV) is a dreaded side effect of chemotherapy that remains common despite substantial advances in antiemetic treatments. Cannabis products have long had a...
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Cannabinoids and triple-negative breast cancer treatment
“Triple-negative breast cancer (TNBC) accounts for about 10-20% of all breast cancer cases and is associated with an unfavorable prognosis. Until recently, treatment options for TNBC were limited to...
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A Bioinformatic Analysis Predicts That Cannabidiol Could Function as a...
“Colorectal cancer (CRC), found in the intestinal tract, is initiated and progresses through various mechanisms, including the dysregulation of signaling pathways. Several signaling pathways, such as...
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Cannabidiol exhibits potent anti-cancer activity against...
“Background: Failure of treatment with gemcitabine in most cholangiocarcinoma (CCA) patients is due to drug resistance. The therapeutic potential of natural plant secondary compounds with minimal...
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Cannabidiol enhances Atezolizumab efficacy by upregulating PD-L1 expression...
“The treatment of patients with triple negative breast cancer (TNBC) relies on cytotoxic therapy. Currently, atezolizumab and chemotherapy can be combined in patients with TNBC. However, this approach...
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Mechanistic Insights into the Impact of WIN 55, 212-2, a Synthetic...
“The endocannabinoid (eCB) system comprises endogenous ligands, cannabinoid receptors (CBRs) and proteins involved in their regulation; its alteration leads to many diseases including cancer. Thus,...
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