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Medical cannabis use in oncology and associated outcomes: A scoping review
“Background: Natural and synthetic cannabinoids are being used worldwide to treat various symptoms in cancer patients. This study aims to map the therapeutic benefits and adverse effects associated...
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Anti-proliferative and apoptotic effect of cannabinoids on human pancreatic...
“Human pancreatic ductal adenocarcinoma (PDAC) is a highly malignant and lethal tumor of the exocrine pancreas. Cannabinoids extracted from the hemp plant Cannabis sativa have been suggested as a...
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Synergistic effect of cannabidiol with dasatinib on lung cancer by...
“Dasatinib-related resistance frequently occurs and may lead to the failure of chemotherapy; thus, dose interruptions are necessary. Cannabidiol (CBD) has potential for integration with orthodox...
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A Comparative Analysis on the Potential Anticancer Properties of...
“Objective: The purpose of this study is to comparatively analyze the anticancer properties of Tetrahydrocannabinol (THC), Cannabidiol (CBD), and Tetrahydrocannabivarin (THCV) using In silico tools....
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Discovering single cannabidiol or synergistic antitumor effects of...
“Introduction: A multitude of findings from cell cultures and animal studies are available to support the anti-cancer properties of cannabidiol (CBD). Since CBD acts on multiple molecular targets, its...
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Cannabidiol induces ERK activation and ROS production to promote autophagy...
“Small molecule-driven ERK activation is known to induce autophagy and ferroptosis in cancer cells. Herein the effect of cannabidiol (CBD), a phytochemical derived from Cannabis sativa, on ERK-driven...
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Cannabidiol Inhibits Epithelial Ovarian Cancer: Role of Gut Microbiome
“Epithelial ovarian cancer is among the deadliest gynecological tumors worldwide. Clinical treatment usually consists of surgery and adjuvant chemo- and radiotherapies. Due to the high rate of...
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Cannabis use disorder and perioperative outcomes following complex cancer...
“Introduction: Cannabis usage is increasing in the United States, especially among patients with cancer. We sought to evaluate whether cannabis use disorder (CUD) was associated with higher morbidity...
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Water Extracts from Industrial Hemp Waste Inhibit the Adhesion and...
“The evolution of regulatory perspectives regarding the health and nutritional properties of industrial hemp-based products (Cannabis sativa L.) has pushed research to focus on the development of new...
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The Use of Tetrahydrocannabinol Is Associated with an Increase in Survival...
“Introduction: Tetrahydrocannabinol (THC) is often prescribed for ambulatory palliative patients to improve sleep quality and appetite and to reduce anxiety, stress, and pain. However, it is not known...
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Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of...
“Cisplatin and other platinum-derived chemotherapy drugs have been used for the treatment of cancer for a long time and are often combined with other medications. Unfortunately, tumours often develop...
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Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the...
“In our previous study, we demonstrated the impact of overexpression of CB1 and CB2 cannabinoid receptors and the inhibitory effect of endocannabinoids (2-arachidonoylglycerol (2-AG) and Anandamide...
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Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative...
“Cannabis and its major cannabinoid cannabidiol (CBD) are reported to exhibit anticancer activity against skin tumors. However, the cytotoxic effects of other minor cannabinoids and synthetic CBD...
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Phytocannabinoids CBD, CBG, and their Derivatives CBD-HQ and CBG-A Induced In...
“Phytocannabinoids, compounds found in Cannabis sativa L., are used in oncology and palliative care to reduce the adverse reactions of standard therapies. Cancer patients use formulations of Cannabis...
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Paclitaxel-Associated Mechanical Sensitivity and Neuroinflammation Are Sex-,...
“Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent and dose-limiting complications in chemotherapy patients. One identified mechanism underlying CIPN is neuroinflammation....
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Altering biomolecular condensates as a potential mechanism that mediates...
“Glioblastoma (GBM) is an extremely aggressive primary brain tumor with poor prognosis, short survival time post-diagnosis and high recurrence. Currently, no cure for GBM exists. The identification of...
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In silico investigation of cannabinoids from Cannabis sativa leaves as a...
“Genes related to MAPK-ERK signaling pathways, and epithelial-mesenchymal transition induction is evolutionarily conserved and has crucial roles in the regulation of important cellular processes,...
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Cannabidiol’s cytotoxicity in pancreatic cancer is induced via an...
“Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a median 5 year-survival rate of 12%. Cannabidiol (CBD) has been found to exhibit antineoplastic potential...
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Mitochondrial calcium overload contributes to cannabinoid-induced paraptosis...
“Studies have shown that natural products can induce paraptosis in tumour cell lines. Paraptosis is characterized by cytoplasmic vacuolation arising from the endoplasmic reticulum (ER) and...
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Research Progress on the Mechanism of the Antitumor Effects of Cannabidiol
“Cannabidiol (CBD), a non-psychoactive ingredient extracted from the hemp plant, has shown therapeutic effects in a variety of diseases, including anxiety, nervous system disorders, inflammation, and...
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