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Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role...
“The development and progression of cancer are associated with the dysregulation of multiple pathways involved in cell proliferation and survival, as well as dysfunction in redox balance, immune...
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A label free chemoproteomic-based platform to disclose cannabidiol molecular...
“The discovery of the interactome of cannabidiol (CBD), a non-psychoactive cannabinoid from Cannabis sativa L., has been here performed on chronic myelogenous leukemia cancer cells, using an optimized...
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Effectiveness of cannabidiol (CBD) on histopathological changes and gene...
“The third most prevalent malignancy to cause mortality is hepatocellular carcinoma (HCC). The Hedgehog (Hh) signaling pathway is activated by binding to the transmembrane receptor Patched-1 (PTCH-1),...
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Cannabis use among cancer patients and survivors in the United States: a...
“Background: How cannabis products are being used by cancer patients and survivors in the U.S is poorly understood. This study reviewed observational data to understand the modes, patterns, reasons,...
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Pain management for post-treatment survivors of complex cancers: a...
“Aim: We aimed to understand experiences with opioids and cannabis for post-treatment cancer survivors. Patients & methods: We conducted seven focus groups among head and neck and lung cancer...
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Cannabis Perceptions and Patterns of Use Among Older Adult Cancer Survivors
“Objectives: To descriptively assess cannabis perceptions and patterns of use among older adult cancer survivors in a state without a legal cannabis marketplace. Methods: This study used weighted...
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Integrated transcriptome and cell phenotype analysis suggest involvement of...
“Introduction: Cannabis sativa is utilized mainly for palliative care worldwide. Ovarian cancer (OC) is a lethal gynecologic cancer. A particular cannabis extract fraction (‘F7’) and the...
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Evaluating the Mechanism of Cell Death in Melanoma Induced by the Cannabis...
“Research suggests the potential of using cannabinoid-derived compounds to function as anticancer agents against melanoma cells. Our recent study highlighted the remarkable in vitro anticancer effects...
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Targeting the Endocannabinoid System Present in the Glioblastoma Tumour...
“The highly aggressive and invasive glioblastoma (GBM) tumour is the most malignant lesion among adult-type diffuse gliomas, representing the most common primary brain tumour in the neuro-oncology...
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Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and...
“Mitogen-activated protein kinase (MAPK) activation by natural compounds is known to be involved in the induction of apoptosis, paraptosis, and autophagy. Cannabidiol (CBD), a bioactive compound found...
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Cannabigerol Induces Autophagic Cell Death by Inhibiting EGFR-RAS Pathways in...
“Pancreatic ductal adenocarcinoma (PDAC) is the most frequent infiltrating type of pancreatic cancer. The poor prognosis associated with this cancer is due to the absence of specific biomarkers,...
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Cannabidiol protects C2C12 myotubes against cisplatin-induced atrophy by...
“Cancer and chemotherapy can both cause cachexia, a complex multi-organ syndrome characterized by body weight loss, due to adipose tissue and skeletal muscle wasting. Changes in body weight and muscle...
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The effects of cannabidiol against Methotrexate-induced lung damage
“Methotrexate (MTX) is a widely used medication for various cancers, yet its use is associated with adverse effects on organs, notably the lungs. Cannabidiol (CBD), known for its antioxidant and...
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Cannabinoids for Cancer-related Pain Management: An Update on Therapeutic...
“Pain is a debilitating phenomenon that dramatically impairs the quality of life of patients. Many chronic conditions, including cancer, are associated with chronic pain. Despite pharmacological...
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Supporting gut health with medicinal cannabis in people with advanced cancer:...
“The side effects of cancer therapy continue to cause significant health and cost burden to the patient, their friends and family, and governments. A major barrier in the way in which these side...
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Cannabinoids in the treatment of glioblastoma
“Glioblastoma (GBM) is the most prevalent primary malignant tumor of the nervous system. While the treatment of other neoplasms is increasingly more efficacious the median survival rate of GBM...
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Classical cannabinoid receptors as target in cancer-induced bone pain: a...
“To test the hypothesis that genetic and pharmacological modulation of the classical cannabinoid type 1 (CB1) and 2 (CB2) receptors attenuate cancer-induced bone pain, we searched Medline, Web of...
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Cannabinoids induce cell death in leukaemic cells through Parthanatos and...
“Background: Several studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is mostly present in hematopoietic stem cells (HSC). The present study evaluates...
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Canonical DDR activation by EMT inducing agent 5-Fluorouracil is modulated by...
“Anastasis cascade including induction of Epithelial to Mesenchymal Transition (EMT), DNA repair, and stimulation of pro-survival mediators collectively exaggerate therapy resistance in cancer...
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Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and...
“Chemotherapy resistance is an insurmountable problem in clinical anticancer therapy. Although Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer (CRC), it still...
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