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Elucidation of GPR55-Associated Signaling behind THC and LPI Reducing Effects...
“GPR55 is involved in many physiological and pathological processes. In cancer, GPR55 has been described to show accelerating and decelerating effects in tumor progression resulting from distinct...
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Characterization of the Chemopreventive Properties of Cannabis sativa L....
“Hemp bioproducts hold great promise as valuable materials for nutraceutical and pharmaceutical applications due to their diverse bioactive compounds and potential health benefits. In line with this...
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Cancer-Cachexia-Induced Human Skeletal Muscle Myotube Degeneration Is...
“Cachexia syndrome, leading to reduced skeletal muscle and fat mass, is highly prevalent in cancer patients, resulting in further negative implications for these patients. To date, there is no...
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Cannabis as a Source of Approved Drugs: A New Look at an Old Problem
“Cannabis plants have been used in medicine since ancient times. They are well known for their anti-diabetic, anti-inflammatory, neuroprotective, anti-cancer, anti-oxidative, anti-microbial,...
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In Vitro Evidence of Selective Pro-Apoptotic Action of the Pure Cannabidiol...
“Plant cannabinoids, secondary metabolites of species belonging to the Cannabis genus, can mimic the endocannabinoids’ action and exert biological effects. Considering the contribution of the...
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Metallothionein Family Proteins as Regulators of Zinc Ions Synergistically...
“Cannabidiol (CBD) is a chemical obtained from Cannabis sativa; it has therapeutic effects on anxiety and cognition and anti-inflammatory properties. Although pharmacological applications of CBD in...
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Divergent synthesis of fractionated Cannabis sativa extract led to multiple...
“Here, we present an interesting, previously unreported method for fractionating a particular class of cannabinoids from the crude leaf extract of Cannabis sativa using HP-20 resins. In this study, we...
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Impact of Low-Dose Dronabinol Therapy on Cognitive Function in Cancer...
“Background: Cannabis may offer therapeutic benefits to patients with advanced cancer not responding adequately to conventional palliative treatment. However, tolerability is a major concern....
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Investigation of the cytotoxicity induced by cannabinoids on human ovarian...
“Cannabinoids have been shown to induce anti-tumor activity in a variety of carcinoma cells such as breast, prostate, and brain. The aim of the present study is to investigate the anti-tumor activity...
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Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role...
“The development and progression of cancer are associated with the dysregulation of multiple pathways involved in cell proliferation and survival, as well as dysfunction in redox balance, immune...
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Cannabigerolic Acid (CBGA) Inhibits the TRPM7 Ion Channel Through its Kinase...
“Cannabinoids are a major class of compounds produced by the plant Cannabis sativa. Previous work has demonstrated that the main cannabinoids cannabidiol (CBD) and tetrahydrocannabinol (THC) can have...
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Awareness and interest in cannabis use for cancer management among cancer...
“Background: We examined the awareness, interest, and information sources relating to cannabis use for cancer management (including management of cancer symptoms and treatment-related side effects)...
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Cannabinoids in the treatment of cancer anorexia and cachexia: Where have we...
“Cachexia-anorexia cancer syndrome remains an unmet clinical need with a dearth of treatment and no standard of care. Acting through the endocannabinoid system, cannabinoids are one potential cancer...
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Cannabinoids in Treating Chemotherapy-Induced Nausea and Vomiting,...
“Cannabis has been used as an herbal remedy for thousands of years, and recent research indicates promising new uses in medicine. So far, some studies have shown cannabinoids to be safe in helping...
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A randomised phase II trial of temozolomide with or without cannabinoids in...
“Background: Glioblastoma (GBM) is the most common adult malignant brain tumour, with an incidence of 5 per 100,000 per year in England. Patients with tumours showing O6-methylguanine-DNA...
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Current cannabis use and pain management among US cancer patients
“Background: National studies reporting the prevalence of cannabis use have focused on individuals with a history of cancer without distinction by their treatment status, which can impact symptom...
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Cannabidiol Combination Enhances Photodynamic Therapy Effects on MCF-7 Breast...
“Cannabis sativa is a well-known plant for its psychoactive effects; however, its many derivatives, such as Cannabidiol (CBD), contain several therapeutic applications. Tetrahydrocannabinol (THC) is...
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Buds and Bugs: A Fascinating Tale of Gut Microbiota and Cannabis in the Fight...
“Emerging research has revealed a complex bidirectional interaction between the gut microbiome and cannabis. Preclinical studies have demonstrated that the gut microbiota can significantly influence...
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Role of Cannabinoids in Oral Cancer
“Cannabinoids have incited scientific interest in different conditions, including malignancy, due to increased exposure to cannabis. Furthermore, cannabinoids are increasingly used to alleviate...
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Oral Cannabidiol Treatment Is Associated with an Anti-Inflammatory Gene...
“Introduction: HIV-related comorbidities appear to be related to chronic inflammation, a condition characterizing people living with HIV (PLWH). Prior work indicates that cannabidiol (CBD) might...
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