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Antitumoral effects of cannabis in Notch1-mutated T-cell acute lymphoblastic...
“In T-cell acute lymphoblastic leukemia (T-ALL), an aggressive hematologic cancer with poor clinical outcomes, more than 50% of cases show NOTCH1-driven transformation [1]. The NOTCH1 receptor...
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Repositioning Cannabinoids and Terpenes as Novel EGFR-TKIs Candidates for...
“This study examines the potential of Cannabis sativa L. plants to be repurposed as therapeutic agents for cancer treatment through designing of hybrid Epidermal growth factor receptor tyrosine kinase...
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Medical cannabis is effective for cancer-related pain: Quebec Cannabis...
“Objectives: To evaluate the safety and effectiveness of medical cannabis (MC) in reducing pain and concurrent medications in patients with cancer. Methods: This study analysed data collected from...
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Therapeutic targeting of the tumor microenvironments with cannabinoids and...
“Cancer is a major global public health concern that affects both industrialized and developing nations. Current cancer chemotherapeutic options are limited by side effects, but plant-derived...
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Antitumor mechanism of cannabidiol hidden behind cancer hallmarks
“Cannabinoids have been utilized for recreational and therapeutic purposes for over 4,000 years. As the primary ingredient in exogenous cannabinoids, Cannabidiol (CBD) has drawn a lot of interest from...
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A Phase I Dose Escalation and Expansion Study of Epidiolex (Cannabidiol) in...
“Purpose: Cannabinoids (CBD) have anti-tumor activity against prostate cancer (PCa). Preclinical studies have demonstrated a significant decrease in prostate specific antigen (PSA) protein expression...
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Neuronal Cannabinoid CB1 Receptors Suppress the Growth of Melanoma Brain...
“Melanoma is one of the deadliest forms of cancer. Most melanoma deaths are caused by distant metastases in several organs, especially the brain, the so-called melanoma brain metastases (MBMs)....
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The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Non-Melanoma Skin Cancer
“Five million non-melanoma skin cancers occur globally each year, and it is one of the most common malignant cancers. The dysregulation of the endocannabinoid system, particularly cannabinoid receptor...
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Cannabidiol as a Promising Adjuvant Therapy for Estrogen Receptor-Positive...
“Background: Estrogen receptor-positive (ER+) breast cancer is the most diagnosed subtype, with aromatase inhibitors (AIs) being one of the therapeutic drug types used in the clinic. However,...
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Cannabinoid compounds in combination with curcumin and piperine display an...
“Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and...
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Study of Cannabis Oils Obtained from Three Varieties of C. sativa and by Two...
“Currently, much effort is being placed into obtaining extracts and/or essential oils from Cannabis sativa L. for specific therapeutic purposes or pharmacological compositions. These potential...
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Effervescent cannabidiol solid dispersion-doped dissolving microneedles for...
“Background: Conventional dissolving microneedles (DMNs) face significant challenges in anti-melanoma therapy due to the lack of active thrust to achieve efficient transdermal drug delivery and...
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Cannabis sativa L. modulates altered metabolic pathways involved in key...
“The present study investigated the ability of Cannabis sativa leaves infusion (CSI) to modulate major metabolisms implicated in cancer cells survival, as well as to induce cell death in human breast...
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Cannabinoids Reduce Melanoma Cell Viability and Do Not Interfere with...
“Background: Cannabinoids are mainly used for recreational purposes, but also made their way into oncology, since these substances can be taken to increase appetite in tumour cachexia. Since there are...
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Antitumor Effects of Cannabis sativa Bioactive Compounds on Colorectal...
“Cannabis sativa is a multipurpose plant that has been used in medicine for centuries. Recently, considerable research has focused on the bioactive compounds of this plant, particularly cannabinoids...
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Use of Medical Cannabis by Patients with Cancer: Attitudes, Knowledge, and...
“Objectives: The study sought to assess factors contributing to the demand for MC among patients with cancer. Methods: Patients applying for a permit to receive MC at a pain and palliative clinic of a...
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Exosomal delivery of cannabinoids against cancer
“Exosomes are extracellular vesicles (EVs) originating from endosomes that play a role in cellular communication. These vesicles which mimic the parental cells that release them are promising...
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Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms...
“During solid tumor progression, the tumor microenvironment (TME) evolves into a highly immunosuppressive milieu. Key players in the immunosuppressive environment are regulatory myeloid cells,...
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Cannabis sativa demonstrates anti-hepatocellular carcinoma potentials in...
“Background: Targeting protein kinase B (Akt) and its downstream signaling proteins are promising options in designing novel and potent drug candidates against hepatocellular carcinoma (HCC). The...
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Prevention of Taste Alterations in Patients with Cancer Receiving Paclitaxel-...
“Introduction: Taste alteration is a common adverse effect of chemotherapy. This study aimed to investigate the effect of cannabidiol (CBD) on Lean Body Mass (LBM), and taste alterations during...
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