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Human lung-resident macrophages express CB1 and CB2 receptors whose...
“Macrophages are pivotal effector cells in immune responses and tissue remodeling by producing a wide spectrum of mediators, including angiogenic and lymphangiogenic factors. Activation of cannabinoid...
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Plant derived substances with anti-cancer activity: from folklore to practice.
“Plants have had an essential role in the folklore of ancient cultures. In addition to the use as food and spices, plants have also been utilized as medicines for over 5000 years. It is estimated that...
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Cannabinoids and cancer: potential for colorectal cancer therapy.
“Despite extensive research into the biology of CRC (colorectal cancer), and recent advances in surgical techniques and chemotherapy, CRC continues to be a major cause of death throughout the world....
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Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in...
“The endocannabinoid system is comprised of cannabinoid receptors (CB1 and CB2), their endogenous ligands (endocannabinoids), and proteins responsible for their metabolism participate in many different...
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Cannabinoids for nausea and vomiting in adults with cancer receiving...
“Cannabis has a long history of medicinal use. Cannabis-based medications (cannabinoids) are based on its active element, delta-9-tetrahydrocannabinol (THC), and have been approved for medical...
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Controlled release tablet formulation containing natural δ9...
“Cannabinoids are increasingly being used in the treatment of chemotherapy induced nausea and vomiting (CINV) because of their action on the cannabinoid receptors, CB1 and CB2. The currently marketed...
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Potentiation of the antitumor activity of adriamycin against osteosarcoma by...
“Osteosarcoma is the most frequent primary malignant bone tumor that occurs in children and adolescents. Osteosarcoma is a bone malignancy that predominantly affects children and adolescents, and...
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The therapeutic aspects of the endocannabinoid system (ECS) for cancer and...
“The endocannabinoid system (ECS) is a group of neuromodulatory lipids and their receptors, which are widely distributed in mammalian tissues. ECS regulates various cardiovascular, nervous, and immune...
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Cannabis ‘Can Reduce Tumour Growth’, Expert Says
“He believes chemicals in cannabis could be anti-cancer agents” “Marijuana is now used by cancer patients in some countries to ease the pain of their illness – but it might actually offer a...
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Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are...
“Quercetin, the major constituent of flavonoid and widely present in fruits and vegetables, is an attractive compound for cancer prevention due to its beneficial anti proliferative effects, showing a...
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Ligands for cannabinoid receptors, promising anticancer agents.
“Cannabinoids compounds are unique to cannabis and provide some interesting biological properties. These compounds along with endocannabinoids, a group of neuromodulator compounds in the body...
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Cannabinoids inhibit cellular respiration of human oral cancer cells.
“The primary cannabinoids, Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and Delta(8)-tetrahydrocannabinol (Delta(8)-THC) are known to disturb the mitochondrial function and possess antitumor...
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Dronabinol has preferential antileukemic activity in acute lymphoblastic and...
“It has been previously demonstrated in several cancer models, that Dronabinol (THC) may have anti-tumor activity – however, controversial data exists for acute leukemia. We have anecdotal evidence...
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Granite City Man Claims Cannabis Oil Cured His ‘Incurable’ Cancer
“Darren Miller is ready to enjoy his second chance at life. The 50-year-old Granite City man is putting out the word that a steady diet of cannabis oil coupled with chemotherapy wiped out what doctors...
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Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine...
“The G-protein-coupled chemokine receptor, CXCR4, generates signals that lead to cell migration, cell proliferation, and other survival mechanisms which result in the metastatic spread of primary tumor...
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Medicinal cannabis.
“A number of therapeutic uses of cannabis and its derivatives have been postulated from preclinical investigations. Possible clinical indications include spasticity and pain in multiple sclerosis,...
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Cannabinoid pharmacology in cancer research: A new hope for cancer patients?
“Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of pathophysiological conditions, such as mood and...
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Smoking marijuana reduces cancer risk
“Marijuana reduces cancer risk and kills existing tumors” “This may be hard to believe — as we’re fairly accustomed to the notion that inhaling smoke is always bad for your health — but research shows...
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Endocannabinoids as Guardians of Metastasis.
“Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and...
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Natural product modulators of transient receptor potential (TRP) channels as...
“Treatment of cancer is a significant challenge in clinical medicine, and its research is a top priority in chemical biology and drug discovery. Consequently, there is an urgent need for identifying...
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