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Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy...
“Endogenous and exogenous cannabinoids modulate many physiological and pathological processes by binding classical cannabinoid receptors 1 (CB1) or 2 (CB2) or non-cannabinoid receptors. Cannabinoids...
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Antitumorigenic Effect of Cannabidiol in Lung Cancer: What Do We Know So...
“Background: Lung cancer remains a major factor contributing to morbidity and mortality worldwide. Apart from the chemotherapeutic agents in routine use, factors targeting novel molecular pathways are...
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Antitumor Effects of Delta (9)-Tetrahydrocannabinol and Cannabinol on...
“Cholangiocarcinoma (CCA) is a very aggressive tumor. The development of a new therapeutic drug for CCA is required. This study aims to evaluate the antitumor effect of ∆9-tetrahydrocannabinol (THC),...
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In Silico Binding Analysis of Cannabinoids with Eph Receptors for Therapeutic...
“Background: Accumulating evidence suggests overexpression of Eph receptors is associated with malignant human gliomas. Inhibiting interactions of Eph receptors with their ephrin ligands may improve...
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Selective Cytotoxicity of Medical Cannabis ( Cannabis sativa L.) Extracts...
“Introduction: The use of Cannabis sativa L. in health care requires stringent care for the optimal production of the bioactive compounds. However, plant phenotypes and the content of secondary...
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The role of Cannabidiol and tetrahydrocannabivarin to overcome doxorubicin...
“The significant resistance to currently available chemotherapeutics makes treatment for TNBC a key clinical concern. Herein, we studied the anti-cancer potentials of synthetic cannabidiol (CBD) and...
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The use of medical cannabis concomitantly with immune checkpoint inhibitors...
“Background: The use of medical cannabis has rapidly increased among cancer patients worldwide. Cannabis is often administered concomitantly with cancer medications, including immune checkpoint...
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Study of potential inhibition of the estrogen receptor α by cannabinoids...
“Breast cancer is the main cancer type with more than 2.2 million cases in 2020, and is the principal cause of death in women; with 685000 deaths in 2020 worldwide. The estrogen receptor is involved...
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Real-Time Monitoring of the Cytotoxic and Antimetastatic Properties of...
“Cannabidiol (CBD) is an active natural compound that is extracted from Cannabis sativa. Previous studies show that CBD is a nonpsychotropic compound with significant anticancer effects. This study...
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Cannabidiol and Its Combinations with Nonsteroidal Anti-Inflammatory Drugs...
“Vulvar squamous cell carcinoma (VSCC) is a rare malignancy with a relatively good prognosis. However, the prognosis remains poor for elderly patients and those with a significant depth of tumor...
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A zebrafish HCT116 xenograft model to predict anandamide outcomes on...
“Colon cancer is one of the leading causes of death worldwide. In recent years, cannabinoids have been extensively studied for their potential anticancer effects and symptom management. Several in...
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Structural analysis of cannabinoids against EGFR-TK leads a novel target...
“Epidermal growth factor receptor (EGFR) is a member of the ErbB family of proteins and are involved in downstream signal transduction, plays prominent roles in cell growth regulation, proliferation,...
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Comparative changes in breast cancer cell proliferation and signalling...
“Breast cancer is the most commonly diagnosed cancer and a leading cause of cancer-related death among women worldwide. Somatostatin (SST) and Cannabinoids have an anti-proliferative and pro-apoptotic...
View Article[A mini-review on anti-tumor effect of cannabidiol]
“Cannabidiol is the main non-psychoactive component of Cannabis sativa, which has multiple medicinal activities, such as antiepileptic, immunomodulation, analgesic, antioxidant, anticonvulsant,...
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Formulation and development of novel lipid-based combinatorial advanced...
“Non-melanoma skin cancer is one of the most common malignancies reported with high number of morbidities, demanding an advanced treatment option with superior chemotherapeutic effects. Due to high...
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Cannabidiol as Self-Assembly Inducer for Anticancer Drug-Based Nanoparticles
“Cannabidiol (CBD) is a biologically active compound present in the plants of the Cannabis family, used as anticonvulsant, anti-inflammatory, anti-anxiety, and more recently, anticancer drug. In this...
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Phytochemical Constituents and Derivatives of Cannabis sativa; Bridging the...
“Melanoma is deadly, physically impairing, and has ongoing treatment deficiencies. Current treatment regimens include surgery, targeted kinase inhibitors, immunotherapy, and combined approaches. Each...
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Therapeutic and Supportive Effects of Cannabinoids in Patients with Brain...
“The potential medicinal properties of Cannabis continue to garner attention, especially in the brain tumor domain. This attention is centered on quality of life and symptom management; however, it is...
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The Effect of Cannabis Plant Extracts on Head and Neck Squamous Cell...
“Cannabis sativa plants have a wide diversity in their metabolite composition among their different chemovars, facilitating diverse anti-tumoral effects on cancer cells. This research examined the...
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Tetrahydrocannabinols: potential cannabimimetic agents for cancer therapy
“Tetrahydrocannabinols (THCs) antagonize the CB1 and CB2 cannabinoid receptors, whose signaling to the endocannabinoid system is essential for controlling cell survival and proliferation as well as...
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