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Anti-Cancer Activity of Cannabis sativa Phytocannabinoids: Molecular...
“Ovarian cancer (OC) is the most lethal gynecological malignancy, with about 70% of cases diagnosed only at an advanced stage. Cannabis sativa, which produces more than 150 phytocannabinoids, is used...
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The antitumor activity of cannabis sativa and CBD in prostate cancer PC3 cells
“Prostate cancer is the second most frequently occurring carcinoma in males worldwide and one of the leading causes of death in men around the world. Recent studies estimate that over 1.4 million...
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Analysis of Anti-Cancer and Anti-Inflammatory Properties of 25 High-THC...
“Cannabis sativa is one of the oldest cultivated plants. Many of the medicinal properties of cannabis are known, although very few cannabis-based formulations became prescribed drugs. Previous...
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Expression of cannabinoid receptors CB1 and CB2 in canine cutaneous mast cell...
“Cannabinoid receptors (CB1 and CB2) belong to endocannabinoid system (ECS), which is also composed from endocannabinoids and the enzymatic systems involved in their biosynthesis and degradation. The...
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Changes in the expression of endocannabinoid system components in an...
“Chemotherapy-induced neuropathic pain is a serious clinical problem and one of the major side effects in cancer treatment. The endocannabinoid system (ECS) plays a crucial role in regulating pain...
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Cannabidiolic acid activates the expression of the PPARβ/δ target genes in...
“Cannabidiolic acid (CBDA) can activate peroxisome proliferator-activated receptor-α (PPARα) and PPARγ. Whether CBDA can activate PPARβ/δ has not been examined sufficiently to date. Since previous...
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The Cytotoxic Effect of Isolated Cannabinoid Extracts on Polypoid Colorectal...
“Purified cannabinoids have been shown to prevent proliferation and induce apoptosis in colorectal carcinoma cell lines. To assess the cytotoxic effect of cannabinoid extracts and purified...
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Oxidative Stress and Autophagy Mediate Anti-Cancer Properties of Cannabis...
“Cannabinoids, the active components of cannabis exert palliative effects in cancer patients by preventing nausea, vomiting and pain as well as by stimulating appetite. Recent studies indicated that...
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Pilot clinical and pharmacokinetic study of Δ9-Tetrahydrocannabinol...
“This pilot study aimed to assess the safety, tolerability, pharmacokinetics and exploratory analgesic effect of a novel water-soluble oro-buccal nanoparticle spray of a cannabis-based medicine...
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Design and function of targeted endocannabinoid nanoparticles
“Nanoparticles and nano-delivery systems are constantly being refined and developed for biomedical applications such as imaging, gene therapy, and targeted delivery of drugs. Nanoparticles deliver...
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Anti-cancer effects of selective cannabinoid agonists in pancreatic and...
“Objective: Cancer ranks first among the causes of morbidity and mortality all over the world, and it is expected to continue to be the main cause of death in the coming years. Therefore, new...
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The Synthetic Cannabinoid URB447 Exerts Antitumor and Antimetastatic Effect...
“The endocannabinoid system is widespread through the body and carries out a wide variety of functions. However, its involvement in other pathologies, such as cancer, still needs further attention. We...
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Use of Cannabis and Cannabinoids for Treatment of Cancer
“The endocannabinoid system (ECS) is an ancient homeostasis mechanism operating from embryonic stages to adulthood. It controls the growth and development of many cells and cell lineages....
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Combinations of Cannabidiol and Δ9-Tetrahydrocannabinol in Reducing...
“Neuropathic pain is a condition that impacts a substantial portion of the population and is expected to affect a larger percentage in the future. This type of pain is poorly managed by current...
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Endocannabinoids and related compounds as modulators of angiogenesis:...
“Vasculogenesis (the process of differentiation of angioblasts toward endothelial cells and de novo formation of crude vascular networks) and angiogenesis (the process of harmonized sprouting and...
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Role of Cannabidiol for Improvement of the Quality of Life in Cancer...
“There is currently a growing interest in the use of cannabidiol (CBD) to alleviate the symptoms caused by cancer, including pain, sleep disruption, and anxiety. CBD is often self-administered as an...
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Photodynamic Therapy Efficacy of Novel Zinc Phthalocyanine Tetra Sodium...
“This work reports for the first time on the synthesis, characterization, and photodynamic therapy effect of a novel water-soluble zinc (II) 2(3), 9(10), 16(17), 23(24)-tetrakis-(sodium...
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Phytocannabinoid Compositions from Cannabis Act Synergistically with PARP1...
“Ovarian cancer (OC) is the single most lethal gynecologic malignancy. Cannabis sativa is used to treat various medical conditions, and is cytotoxic to a variety of cancer types. We sought to examine...
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Supercritical Extract of Cannabis sativa Inhibits Lung Metastasis in...
“Colorectal cancer (CRC) is one of the diseases with the highest rates of prevalence and mortality despite therapeutic methods in the world. In particular, there are not enough methods to treat...
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Disorders of cancer metabolism: The therapeutic potential of cannabinoids
“Abnormal energy metabolism, as one of the important hallmarks of cancer, was induced by multiple carcinogenic factors and tumor-specific microenvironments. It comprises aerobic glycolysis, de novo...
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