Cannabinoids as anticancer drugs: current status of preclinical research
“Drugs that target the endocannabinoid system are of interest as pharmacological options to combat cancer and to improve the life quality of cancer patients. From this perspective, cannabinoid...
View ArticlePlant-derived cannabinoids as anticancer agents
“Substantial preclinical evidence demonstrates the antiproliferative, cytotoxic, and antimetastatic properties of plant-derived cannabinoids (phytocannabinoids) such as cannabidiol and...
View ArticleCannabidiol inhibits RAD51 and sensitizes glioblastoma to temozolomide in...
“Background: Cannabidiol (CBD), a nonpsychoactive cannabinoid with a low toxicity profile, has been shown to produce antitumor activity across cancers in part through selective production of reactive...
View ArticleA Low Dose of Pure Cannabidiol Is Sufficient to Stimulate the Cytotoxic...
“Despite numerous studies conducted over the past decade, the exact role of the cannabinoid system in cancer development remains unclear. Though research has focused on two cannabinoid receptors (CB1,...
View ArticleImpact of Cannabinoid Compounds on Skin Cancer
“Drugs targeting the endocannabinoid system are of interest as potential systemic chemotherapeutic treatments and for palliative care in cancer. In this context, cannabinoid compounds have been...
View ArticleA Nrf-2 Stimulatory Hydroxylated Cannabidiol Derivative from Hemp ( Cannabis...
“A phytochemical analysis of mother liquors obtained from crystallization of CBD from hemp (Cannabis sativa), guided by LC-MS/MS and molecular networking profiling and completed by isolation and...
View ArticleCannabidiol Μay Prolong Survival in Patients With Glioblastoma Multiforme
“Background: Glioblastoma multiforme (GBM) is a relatively rare type of brain tumour with an incidence rate around 6 per 100,000. Even with the widely practiced combination of radiotherapy with...
View ArticleThe Endocannabinoid System as a Pharmacological Target for New Cancer Therapies
“Despite the long history of cannabinoid use for medicinal and ritual purposes, an endogenous system of cannabinoid-controlled receptors, as well as their ligands and the enzymes that synthesise and...
View ArticleAnti-cancer potential of cannabis terpenes in a taxol-resistant model of...
“Chemotherapeutic resistance can limit breast cancer outcomes; therefore, the exploration of novel therapeutic options is warranted. Isolated compounds found in cannabis have previously been shown to...
View ArticleCannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells:...
“Cancer is a complex family of diseases affecting millions of people worldwide. Gliomas are primary brain tumors that account for ~80% of all malignant brain tumors. Glioblastoma multiforme (GBM) is...
View ArticleBiophysical Studies and In Vitro Effects of Tumor Cell Lines of Cannabidiol...
“Phytocannabinoids possess anticancer properties, as established in vitro and in vivo. However, they are characterized by high lipophilicity. To improve the properties of cannabidiol (CBD), such as...
View ArticleLower Rates of Hepatocellular Carcinoma Observed Among Cannabis Users: A...
“Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and the fourth leading cause of cancer deaths in the world. The association between HCC and cannabis has...
View ArticleCannabinol inhibits proliferation and induces cell cycle arrest and apoptosis...
“Cannabis sativa is an agriculturally and medicinally important plant with many pharmaceutical properties. Cancer is a deadly disease; it is estimated that it will cause over 80 thousand deaths in...
View ArticleClik here to view.
Cannabinol Inhibits Cellular Proliferation, Invasion, and Angiogenesis of...
“High-risk neuroblastoma is an aggressive pediatric tumor. Despite great advances in neuroblastoma therapy and supportive care protocols, no curative treatment is available for most patients with this...
View ArticleClik here to view.
Activation of cannabinoid receptors in breast cancer cells improves...
“The endocannabinoid system has been postulated to help restrict cancer progression and maintain osteoblastic function during bone metastasis. Herein, the effects of cannabinoid receptor (CB) type 1...
View ArticleClik here to view.
Cutaneous Squamous Cell Carcinoma and Lichen Simplex Chronicus Successfully...
“Cannabidiol is a member of the cannabinoids, consisting of a diverse class of compounds derived from Cannabis sativa. There are three types of cannabinoids based on origin: endocannabinoids...
View ArticleClik here to view.
Synthesis of A Tetrahydrocannabinol (THC) Analog For Analyzing Cellular...
“Cannabinoids have been extensively studied in the field of cancer research. Tetrahydrocannabinol (THC) has shown promising results in influencing cellular proliferation when in association with other...
View ArticleClik here to view.
The Role of Nutritional Status, Gastrointestinal Peptides, and...
“Neoplastic diseases in children are the second most frequent cause of death among the young. It is estimated that 400,000 children worldwide will be diagnosed with cancer each year. The nutritional...
View ArticleClik here to view.
Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor...
“1,8-naphthyridine-3-carboxamide structures were previously identified as a promising scaffold from which to obtain CB2R agonists with anticancer and anti-inflammatory activity. This work describes...
View ArticleClik here to view.
The Role of Cannabidiol (CBD) in a Cisplatin-Induced Model of Chronic...
“Cannabinoid-based therapies offer a safer, non-opioid alternative for the management of chronic pain. While most studies focus on the analgesic potential of the main psychoactive component of...
View Article