Clik here to view.
The effect of cannabidiol on canine neoplastic cell proliferation and MAP...
“Low tetrahydrocannabinol Cannabis sativa products, also known as hemp products, have become widely available and their use in veterinary patients has become increasingly popular. Despite prevalence of...
View ArticleClik here to view.
The Immune Endocannabinoid System of the Tumor Microenvironment
“Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of tumor progression. Because of the immunoregulatory properties of cannabinoids, the endocannabinoid system...
View ArticleClik here to view.
Short-Term Medical Cannabis Treatment Regimens Produced Beneficial Effects...
“In the last decade the use of medical cannabis (MC) for palliative cancer treatment has risen. However, the choice between products is arbitrary and most patients are using Tetrahydrocannabinol...
View ArticleClik here to view.
Effects of standardized Cannabis sativa extract and ionizing radiation in...
“Melanoma causes the highest number of skin cancer-related deaths worldwide. New treatment methods are essential for the management of this life-threatening disease. Aims: In this study, we...
View ArticleClik here to view.
Phenolic Compounds Cannabidiol, Curcumin and Quercetin Cause Mitochondrial...
“Anticancer activity of different phenols is documented, but underlying mechanisms remain elusive. Recently, we have shown that cannabidiol kills the cells of acute lymphoblastic leukemia (ALL) by a...
View ArticleClik here to view.
(Endo)Cannabinoids and Gynaecological Cancers
“Gynaecological cancers can be primary neoplasms, originating either from the reproductive tract or the products of conception, or secondary neoplasms, representative of metastatic disease. For some...
View ArticleClik here to view.
Cannabinoids in Medicine: Cancer, Immunity, and Microbial Diseases
“Recently, there has been a growing interest in the medical applications of Cannabis plants. They owe their unique properties to a group of secondary metabolites known as phytocannabinoids, which are...
View ArticleClik here to view.
Therapeutic potential of cannabinoids in combination cancer therapy
“Derivatives of the plant Cannabis sativa have been used for centuries for both medical and recreational purposes, as well as industrial. The first proof of its medicinal use comes from ancient...
View ArticleClik here to view.
Effects of cannabidiol (CBD) on the inhibition of melanoma cells in vitro
“Cannabidiol (CBD) is one of the most popular emerging plant extracts that is being investigated for its wide range of potential health benefits. This experiment tests how B16 mice melanoma cells,...
View ArticleClik here to view.
Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol...
“Cannabis sativa contains more than 500 constituents, yet the anticancer properties of the vast majority of cannabis compounds remains unknown. We aimed to identify cannabis compounds and their...
View ArticleClik here to view.
The Role of Cannabinoids as Anticancer Agents in Pediatric Oncology
“Cannabinoids are a group of chemicals that bind to receptors in the human body and, in turn, modulate the endocannabinoid system (ECS). They can be endogenously produced, synthetic, or derived from...
View ArticleClik here to view.
The pro-apoptosis effects of Echinacea purpurea and Cannabis sativa extracts...
“Considering the advantages of using medicinal herbs as supplementary treatments to sensitize conventional anti-cancer drugs, studying functional mechanisms and regulatory effects of Echinacea...
View ArticleClik here to view.
Induced Fit Docking and Automated QSAR Studies Reveal the ER-α Inhibitory...
“Background: Breast Cancer (BC), a common death-causing disease and the deadliest cancer next to lung cancer, is characterized by an abnormal growth of cells in the tissues of the breast. BC...
View ArticleClik here to view.
Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for...
“Glioblastoma is the most aggressive cancer among primary brain tumours. As with other cancers, the incidence of glioblastoma is increasing; despite modern therapies, the overall mean survival of...
View ArticleClik here to view.
Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways...
“Glioblastomas (GBMs) are aggressive brain tumors with frequent genetic alterations in TP53 and PTEN tumor suppressor genes rendering resistance to standard chemotherapeutics. Cannabinoid type 1 and 2...
View ArticleClik here to view.
A phase 1b randomised, placebo-controlled trial of nabiximols cannabinoid...
“Preclinical data suggest some cannabinoids may exert antitumour effects against glioblastoma (GBM). Safety and preliminary efficacy of nabiximols oromucosal cannabinoid spray plus dose-intense...
View ArticleClik here to view.
Cannabidiol inhibits human glioma by induction of lethal mitophagy through...
“Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been shown to be effective...
View ArticleClik here to view.
CBD activation of TRPV1 induces oxidative signalling and subsequent ER stress...
“Endoplasmic reticulum (ER) stress is an imbalance between the ER’s protein-folding load and capacity. It can be induced by various physiological conditions, activating the unfolded protein response to...
View ArticleClik here to view.
A cannabidiol-loaded Mg-gallate metal-organic framework-based potential...
“Cannabidiol (CBD) has been shown to slow cancer cell growth and is toxic to human glioblastoma cell lines. Thus, CBD could be an effective therapeutic for glioblastoma. In the present study, we...
View ArticleClik here to view.
Emerging role of cannabinoids and synthetic cannabinoid receptor...
“Cannabis was extensively utilized for its medicinal properties till the 19th century. A steep decline in its medicinal usage was observed later due to its emergence as an illegal recreational drug....
View Article