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The Effects of Cannabidiol and Prognostic Role of TRPV2 in Human Endometrial...
“Several studies support, both in vitro and in vivo, the anti-cancer effects of cannabidiol (CBD), a transient receptor potential vanilloid 2 (TRPV2) ligand. TRPV2, often dysregulated in tumors, is...
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Cannabinoid Effects on Experimental Colorectal Cancer Models Reduce Aberrant...
“Colorectal cancer represents a heavy burden for health systems worldwide, being the third most common cancer worldwide. Despite the breakthroughs in medicine, current chemotherapeutic options...
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Roles of Cannabinoids in Melanoma: Evidence from In Vivo Studies
“Melanoma is the fourth most common type of cancer diagnosed in Australians after breast, prostate, and colorectal cancers. While there has been substantial progress in the treatment of cancer in...
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Anti-proliferative and cytotoxic effect of cannabidiol on human cancer cell...
“Objective: Cannabinoids are able to reduce tumor growth in xenograft models, but their therapeutic potential as anti-cancer drugs in humans is unclear yet. In vitro studies of the effect of...
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Cannabis sativa L. Extracts can reverse drug resistance in colorectal...
“Multidrug resistance (MDR) to known chemotherapeutic agents is increasing while the development of new drugs is lacking behind. Combination therapies might increase the development of effective...
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Cannabinoids and Prostate Cancer: A Systematic Review of Animal Studies
“Prostate cancer is a major cause of death among men worldwide. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation, as well as potential...
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Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer...
” Here we show that delta-9-tetrahydrocannabinol (THC) attenuates colitis-associated colon cancer and colitis induced by anti-CD40. THC can prevent the development of colitis-associated colon cancer...
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Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human...
“Pancreatic cancer (PC) is related to lifestyle risks, chronic inflammation, and germline mutations in BRCA1/2, ATM, MLH1, TP53, or CDKN2A. Surgical resection and adjuvant chemotherapy are the main...
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An Agathokakological tale of ∆9 -THC: Exploration of Possible Biological Targets
“∆ 9 -Tetrahydrocannabinol (∆9 -THC), the active phytocannabinoid in cannabis, is virtually an adjunct to the endogenous endocannabinoid signaling system. By interacting with G-protein-coupled...
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Cancer patients’ experiences with medicinal cannabis-related care
“Background: Little is known about medical cannabis (MC)-related care for patients with cancer using MC. Methods: Semistructured telephone interviews were conducted in a convenience sample of...
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Education and communication are critical to effectively incorporating...
“Providers need to be better equipped to discuss medical cannabis with patients even if they are not willing to prescribe it. The oncology community would be well served to ensure that providers are...
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Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast...
“This study evaluated the synergistic anti-cancer potential of cannabinoid combinations across the MDA-MB-231 and MCF-7 human breast cancer cell lines. Cannabinoids were combined and their synergistic...
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Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective...
“The cannabinoid receptor subtype 2 (CB2R) represents an interesting and new therapeutic target for its involvement in the first steps of neurodegeneration as well as in cancer onset and progression....
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Update on cannabis and cannabinoids for cancer pain
“The prevalence of cancer pain will continue to rise as pain is common among the survivorship and general cancer population. As interest in cannabis and cannabinoids for medicinal use including pain...
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Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated...
“The anti-cancer effects of cannabinoids including CBD (Cannabidiol) and THC ((-)-trans-∆9-tetrahydrocannabinol) have been reported in the case of pancreatic cancer (PC). The connection of these...
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Cannabidiol (CBD) as a Promising Anti-Cancer Drug
“Recently, cannabinoids, such as cannabidiol (CBD) and Δ9 -tetrahydrocannabinol (THC), have been the subject of intensive research and heavy scrutiny. Cannabinoids encompass a wide array of organic...
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Preliminary assessment of medical cannabis consumption by cancer survivors
“Objectives: To assess the motivation of cancer survivors to consume medical cannabis and to assess the patterns of use, perceived efficacy, as well as side and adverse effects. Results: The mean...
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Prescribed medical cannabis in women with gynecologic malignancies: A...
“Research within a gynecologic oncology population has lagged behind the uptake in use of medical cannabis for symptom control. This study seeks to evaluate patient experience with prescribed medical...
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Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck...
“Cannabidiol (CBD) has anti-tumorigenic activity. However, the anti-cancer effect of CBD on head and neck squamous cell carcinoma (HNSCC) remains unclear. The cytotoxicity of CBD on HNSCC was...
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Cannabis and its Constituents for Cancer: History, Biogenesis, Chemistry and...
“Cannabis has long been used for healing and recreation in several regions of the world. Over 400 bioactive constituents, including more than 100 phytocannabinoids, have been isolated from this...
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