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n-3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and...
“Over the last decades a renewed interest in n-3 very long polyunsaturated fatty acids (PUFAs), derived mainly from fish oils in the human diet, has been observed because of their potential effects...
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Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231...
“A growing body of experimental evidence strongly suggests that cannabidiolic acid (CBDA), a major component of the fiber-type cannabis plant, exerts a variety of biological activities. We have...
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CBD Reverts the Mesenchymal Invasive Phenotype of Breast Cancer Cells Induced...
“Cannabidiol (CBD) has been used to treat a variety of cancers and inflammatory conditions with controversial results. In previous work, we have shown that breast cancer MCF-7 cells, selected by their...
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Cannabinoids as anticancer therapeutic agents.
“The recent announcement of marijuana legalization in Canada spiked many discussions about potential health benefits of Cannabis sativa. Cannabinoids are active chemical compounds produced by...
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The effects of cannabinoids in exemestane-resistant breast cancer cells: PS181.
“Exemestane is one of the aromatase inhibitors (AI) used as first line treatment for estrogen-receptor positive breast cancer in post-menopausal women. Exemestane acts by inhibiting aromatase, the...
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Synergistic cytotoxic activity of cannabinoids from cannabis sativa against...
“Cannabis sativa produces hundreds of phytocannabinoids and terpenes. Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL), characterized by patches, plaques and tumors....
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Possible Enhancement of Photodynamic Therapy (PDT) Colorectal Cancer...
“Colorectal cancer (CRC) has a high mortality rate and is one of the most difficult diseases to manage due to tumour resistance and metastasis. The treatment of choice for CRC is reliant on the phase...
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Novel approaches and current challenges with targeting the endocannabinoid...
“The pathophysiological relevance of the endocannabinoid system has been widely demonstrated in a variety of diseases including cancer, neurological disorders, and metabolic issues. Therefore,...
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Can Hemp Help? Low-THC Cannabis and Non-THC Cannabinoids for the Treatment of...
“Cannabis has been used to relieve the symptoms of disease for thousands of years. However, social and political biases have limited effective interrogation of the potential benefits of cannabis and...
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Cannabis and cannabinoids in cancer pain management.
“An increasing number of patients are turning to cannabis and cannabinoids for management of their palliative and nonpalliative cancer pain and other cancer-related symptoms. Canadians have a legal...
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Potential therapeutic treatments of cancer-induced bone pain.
“The treatment of cancer-induced bone pain (CIBP) has been proven ineffective and relies heavily on opioids, the target of highly visible criticism for their negative side effects. Alternative...
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PLGA Nanoparticles for the Intraperitoneal Administration of CBD in the...
“The intraperitoneal administration of chemotherapeutics has emerged as a potential route in ovarian cancer treatment. Nanoparticles as carriers for these agents could be interesting by increasing the...
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Inhibitor of Differentiation 1 (Id1) in Cancer and Cancer Therapy.
“The inhibitor of DNA binding (Id) proteins are regulators of cell cycle and cell differentiation. Of all Id family proteins, Id1 is mostly linked to tumorigenesis, cellular senescence as well as cell...
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Cannabinoid CP55940 Selectively Induces Apoptosis in Jurkat Cells and in Ex...
‘T-cell acute lymphoblastic leukemia (T-ALL) is a highly heterogeneous malignant hematological disorder arising from T-cell progenitors. This study was aimed to evaluate the cytotoxic effect of...
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Cannabis, the Endocannabinoid System and Immunity-the Journey From the...
“The Cannabis plant contains numerous components, including cannabinoids and other active molecules. The phyto-cannabinoid activity is mediated by the endocannabinoid system. Cannabinoids affect the...
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The Expression Level of Cannabinoid Receptors Type 1 and 2 in the Different...
“Astrocytomas, the most prevalent primary brain tumors, can be divided by histology and malignancy levels into four following types: pilocytic astrocytoma (grade I), diffuse fibrillary astrocytoma...
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Anticancer Effect of New Cannabinoids Derived From Tetrahydrocannabinolic...
“New tetrahydrocannabinolic acid (THCA) derivatives ALAM027 and ALAM108 were proposed for the treatment of the pancreatic cancer disease. Methods: The in vitro effect of new cannabinoids ALAM027 and...
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Enhancing ovarian cancer conventional chemotherapy through the combination...
“In this work, we evaluated, for the first time, the antitumor effect of cannabidiol (CBD) as monotherapy and in combination with conventional chemotherapeutics in ovarian cancer and developed...
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Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in...
“In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential...
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Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma...
“In this study, we investigated the effects of exposition to IC50 dose for 24 h of a new synthetic cannabinoid (CB83) and of phytocannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on...
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