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Cannabis: A Prehistoric Remedy for the Deficits of Existing and Emerging...

“Cannabis has been used medicinally for centuries and numerous species of this genus are undoubtedly amongst the primeval plant remedies known to humans. Cannabis sativa in particular is the most...

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Anti-Proliferative Properties and Proapoptotic Function of New CB2 Selective...

“Several studies demonstrated that cannabinoids reduce tumor growth, inhibit angiogenesis, and decrease cancer cell migration. As these molecules are well tolerated, it would be interesting to...

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Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced...

  “Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and dose-limiting side effect of cancer treatment that affects millions of cancer survivors throughout the world and current treatment...

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Identification of Synergistic Interaction Between Cannabis-Derived Compounds...

“Colorectal cancer remains the third most common cancer diagnosis and fourth leading cause of cancer-related mortality worldwide. Purified cannabinoids have been reported to prevent proliferation,...

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Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines.

“Studies have emphasized an antineoplastic effect of the non-psychoactive, phyto-cannabinoid, Cannabidiol (CBD). However, the molecular mechanism underlying its antitumor activity is not fully...

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Anti-tumoural actions of cannabinoids.

“The endocannabinoid system has emerged as a considerable target for the treatment of diverse diseases. In addition to the well-established palliative effects of cannabinoids in cancer therapy,...

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Therapeutic applications of cannabinoids.

“The psychoactive properties of cannabinoids are well known and there has been a continuous controversy regarding the usage of these compounds for therapeutic purposes all over the world. Their use...

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GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour...

“The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very few and mostly just palliative treatments are available. As the five years survival...

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Association of Marijuana Use With Psychosocial and Quality of Life Outcomes...

“Is there a difference in quality of life and psychosocial outcomes between marijuana users and nonusers who have newly diagnosed head and neck cancer? In this case-matched cohort study, 74 patients...

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Current natural therapies in the treatment against glioblastoma.

“Glioblastoma (GBM) is the most common and aggressive brain tumor, which causes the highest number of deaths worldwide. It is a highly vascularized tumor, infiltrative, and its tumorigenic capacity is...

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Optimization Of A Preclinical Therapy Of Cannabinoids In Combination With...

  “Glioblastoma multiforme (GBM) is the most frequent and aggressive form of brain cancer. These features are explained at least in part by the high resistance exhibited by these tumors to current...

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Targeting the Endocannabinoid System for Prevention or Treatment of...

“There is a scarcity of drugs to either prevent or properly manage chemotherapy-induced neuropathic pain (CINP). Cannabis or cannabinoids have been reported to improve pain measures in patients with...

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Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV)...

“Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is...

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Cannabinoids in cancer treatment: Therapeutic potential and legislation.

“The plant Cannabis sativa L. has been used as an herbal remedy for centuries and is the most important source of phytocannabinoids. The endocannabinoid system (ECS) consists of receptors, endogenous...

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The Endocannabinoid/Cannabinoid Receptor 2 System Protects Against...

“Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown...

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Targeting Glioma Initiating Cells With A Combined Therapy Of Cannabinoids And...

“Glioblastoma multiforme (GBM) is the most frequent and aggressive type of brain tumor due, at least in part, to its poor response to current anticancer treatments. These features could be explained,...

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Oral cannabinoid-rich THC/CBD cannabis extract for secondary prevention of...

“Chemotherapy-induced nausea and vomiting (CINV) remains an important issue for patients receiving chemotherapy despite guideline-consistent antiemetic therapy. Trials using...

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Care After Chemotherapy: Peripheral Neuropathy, Cannabis for Symptom Control,...

“As cancer therapies improve, patients are living longer. With these improvements in therapy comes a responsibility to optimize patients’ quality of life during cancer therapy and beyond. This report...

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Combined CB2 Receptor Agonist and Photodynamic Therapy Synergistically...

“Triple negative breast cancer (TNBC) is the deadliest form of breast cancer because compared with other types of breast cancer, it is more aggressive, diagnosed at later stage and more likely to...

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Cannabinoid WIN 55,212-2 induces cell cycle arrest and apoptosis, and...

“Cannabinoids have demonstrated anticarcinogenic properties in a variety of malignancies, including in prostate cancer. In the present study, we explored the anti-cancer effects of the synthetic...

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