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Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids
“Many in vitro and in vivo studies have reported on the antitumorigenic effects of plant-derived cannabinoids (CBDs) and their synthetic analogs, including effects in inducing apoptosis and inhibiting...
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Is Cannabidiol a Promising Substance for New Drug Development? A Review of...
“The pharmacological importance of cannabidiol (CBD) has been in study for several years. CBD is the major nonpsychoactive constituent of plant Cannabis sativa and its administration is associated...
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A peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic...
“Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone...
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Endocannabinoid system and anticancer properties of cannabinoids
“Cannabinoids impact human body by binding to cannabinoids receptors (CB1 and CB2). The two main phytocannabinoids are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC interacts with CB1...
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Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs
“Glioblastoma (GBM) is the most malignant brain tumor and one of the deadliest types of solid cancer overall. Despite aggressive therapeutic approaches consisting of maximum safe surgical resection...
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Cannabinoids as a Promising Therapeutic Approach for the Treatment of...
“Gliobalstoma multiforme (GBM) or grade 4 astrocytoma is the most malignant form of primary brain tumor. Treatment of glioblastoma is difficult despite of surgery, radiotherapy and chemotherapy....
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Cannabinoids as potential new therapy for the treatment of gliomas
“Gliomas constitute the most frequent and malignant primary brain tumors. Current standard therapeutic strategies (surgery, radiotherapy and chemotherapeutics, e.g., temozolomide, carmustin or...
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Targeting cannabinoid receptors in gastrointestinal cancers for therapeutic...
“A number of studies have consistently shown that cannabinoids are able to prevent or reduce carcinogenesis in different animal models of colon cancer. Cannabinoids, via CB1 and possibly CB2...
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Novel therapeutic applications of cannabinoids in cancer disease
“The present review shows that cannabinoids exert their anti-cancer effects in a number of ways and in a variety of tissues. The endocannabinoid system is an almost ubiquitous signalling system...
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Anandamide Revisited: How Cholesterol and Ceramides Control...
“Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced...
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Cannabis for the Management of Cancer Symptoms: THC Version 2.0?
“The landscape of medical cannabis is rapidly expanding. Cannabis preparations have been used in medicine for millennia, and now there is a strong renaissance in the study of their therapeutic...
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Involvement of the CB2 cannabinoid receptor in cell growth inhibition and...
“The anti-tumor properties of cannabinoids have been investigated in many in vitro and in vivo studies. Many of these anti-tumor effects are mediated via cannabinoid receptor types 1 and 2 (CB1 and...
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∆9-tetrahydrocannabinol inhibits epithelial-mesenchymal transition and...
“Limited therapeutic interventions are clinically available for treating aggressive endometrial cancer (EC). Therefore, effective therapies are urgently required. Therefore, the present study...
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The role of lipid signaling in the progression of malignant melanoma.
“In the past decades, a vast amount of data accumulated on the role of lipid signaling pathways in the progression of malignant melanoma, the most metastatic/aggressive human cancer type. Genomic...
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Medical Oncologists’ Beliefs, Practices, and Knowledge Regarding Marijuana...
“Although almost every state medical marijuana (MM) law identifies cancer as a qualifying condition, little research supports MM’s use in oncology. We hypothesized that the discrepancy between these...
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Anti-Tumorigenic Properties of Omega-3 Endocannabinoid Epoxides.
“Accumulating studies have linked inflammation to tumor progression. Dietary omega-3 fatty acids including docosahexaenoic acid (DHA) have been shown to suppress tumor growth through their...
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The importance of 15-lipoxygenase inhibitors in cancer treatment.
“Cancer-targeted therapy is an expanding and successful approach in treatment of many types of cancers. One of the main categories of targeted therapy is use of small molecule inhibitors....
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Assessment of Cannabinoids Agonist and Antagonist in Invasion Potential of...
“The prominent hallmark of malignancies is the metastatic spread of cancer cells. Recent studies have reported that the nature of invasive cells could be changed after this phenomenon, causing...
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Appraising the “entourage effect”: antitumor action of a pure cannabinoid...
“Breast cancer is the second leading cause of death among women. Although early diagnosis and development of new treatments have improved their prognosis, many patients present innate or acquired...
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GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions...
“The G protein-coupled receptors 3, 6, and 12 (GPR3, GPR6, and GPR12) comprise a family of closely related orphan receptors with no confirmed endogenous ligands. These receptors are constitutively...
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