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Identification of Terpenoid Chemotypes Among High (−)-trans-Δ9-...
“Cannabis sativa L. (cannabis) is an annual diecious member of the Cannabaceae family. Since ancient times cannabis has been used by humans for its fiber, seed, as well as its psychoactive and...
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A Review of the Therapeutic Antitumor Potential of Cannabinoids.
: “The aim of this review is to discuss cannabinoids from a preclinical and clinical oncological perspective and provide the audience with a concise, retrospective overview of the most significant...
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Use of medical cannabis to reduce pain and improve quality of life in cancer...
“Early attention to pain and symptoms in those with cancer improves both quality of life and survival. Opioid medications are the mainstay treatment of cancer-related pain. Cannabinoids are...
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Cannabinoids as Anticancer Drugs.
“The endocannabinoid system encompassing cannabinoid receptors, endogenous receptor ligands (endocannabinoids), as well as enzymes conferring the synthesis and degradation of endocannabinoids has...
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A selective review of medical cannabis in cancer pain management.
“Insufficient management of cancer-associated chronic and neuropathic pain adversely affects patient quality of life. Patients who do not respond well to opioid analgesics, or have severe side effects...
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Cannabidiol, a novel inverse agonist for GPR12.
“GPR12 is a constitutively active, Gs protein-coupled receptor that currently has no confirmed endogenous ligands. GPR12 may be involved in physiological processes such as maintenance of oocyte...
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Olivia Newton-John champions the use of ‘magical, miracle’ medicinal cannabis
“Let’s get medicinal, says Olivia Newton-John, who has spoken out about the use of medicinal cannabis on a recent visit to Australia. “I will do what I can to encourage it. It’s an important part of...
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Nanoparticle Drones to Target Lung Cancer with Radiosensitizers and Cannabinoids
“Nanotechnology has opened up a new, previously unimaginable world in cancer diagnosis and therapy, leading to the emergence of cancer nanomedicine and nanoparticle-aided radiotherapy. These...
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Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols...
“Prior phase 2/3 studies found that cannabinoids might provide adjunctive analgesia in advanced cancer patients with uncontrolled pain. To assess adjunctive nabiximols (Sativex®), an extract of...
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Medical marijuana in pediatric oncology: A review of the evidence and...
“Medical marijuana (MM) has become increasingly legal at the state level and accessible to children with serious illness. Pediatric patients with cancer may be particularly receptive to MM, given...
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Medical marijuana for the treatment of vismodegib-related muscle spasm
“Basal cell carcinoma (BCC) arises from loss-of-function mutations in tumor suppressor patched homologue 1, which normally inhibits smoothened homologue in the sonic hedgehog signaling pathway....
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Hypothesizing that marijuana smokers are at a significantly lower risk of...
“A hypothetical link between marijuana smoking and cancer has been established based on a number of misleading assumptions. However, recent studies tend to suggest, if anything, an inverse association...
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Cannabis use among patients at a comprehensive cancer center in a state with...
“Cannabis is purported to alleviate symptoms related to cancer treatment, although the patterns of use among cancer patients are not well known. This study was designed to determine the prevalence and...
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Synergistic interaction of the cannabinoid and death receptor systems: A...
“Cannabinoid receptors have been shown to interact with other receptors, including Tumor Necrosis Factor Receptor Superfamily (TNFRS) members, to induce cancer cell death. When cannabinoids and...
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Cannabis sativa Extract Reduces Cytoskeletal Associated Proteins in Breast...
“Cannabis sativa may cause antitumor effects by various mechanisms, including inhibition of cell growth and tumor angiogenesis invasion, induction of cell death, and metastasis. Previous studies...
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Another Breast Cancer Awareness Month. Please Be Aware.
“October is National Breast Cancer Awareness Month, but are you aware of the efficacy of cannabis in treating breast cancer symptoms? There’s even research that suggests cannabis can reverse the...
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The Synthetic Cannabinoid WIN 55,212-2 Elicits Death in Human Cancer Cell Lines.
“Studies have revealed that cancer might be treated with cannabinoids since they can influence cancer cell survival. These findings suggest an alternative treatment option to chemo- and radiotherapy,...
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Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2...
“Cannabinoids include the active constituents of Cannabis or are molecules that mimic the structure and/or function of these Cannabis-derived molecules. Cannabinoids produce many of their cellular and...
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Standardized Cannabis sativa extract attenuates tau and stathmin gene...
“Metastasis is the main cause of death in patients with melanoma. Cannabis-based medicines are effective adjunctive drugs in cancer patients. Tau and Stathmin proteins are the key proteins in cancer...
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Provider Perspectives on Use of Medical Marijuana in Children With Cancer.
“Although medical marijuana (MM) may have utility in the supportive care of children with serious illness, it remains controversial. We investigated interdisciplinary provider perspectives on legal MM...
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