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Cannabidiol mitigates methotrexate-induced hepatic injury via SIRT-1/p53...
“Methotrexate (MTX), a widely used chemotherapeutic agent, often induces hepatotoxicity, limiting its clinical utility. Cannabidiol (CBD), derived from hemp, possesses antioxidant, anti-inflammatory,...
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Improving the Biopharmaceutical Properties of Cannabinoids in Glioblastoma...
“Glioblastoma multiforme (GBM) is the most prevalent primary brain tumor in adults and is known for its rapid proliferation and infiltrative nature. Current therapeutic strategies include surgical...
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Cannabidiol effects in stem cells: A systematic review
“Stem cells play a critical role in human tissue regeneration and repair. In addition, cancer stem cells (CSCs), subpopulations of cancer cells sharing similar characteristics as normal stem cells,...
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Cytotoxicity of natural and synthetic cannabinoids and their synergistic...
“Introduction: Cannabinoids are reported to suppress the growth of ovarian cancer cells, but it is unclear whether structural modifications can improve their cytotoxic effects. Methods: Herein, an...
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Use of Cannabis-Based Medical Products for Pediatric Health Conditions: A...
“Introduction: Cannabis policy is rapidly changing in the USA and across the globe, with 24 states legalizing cannabis for adult use and 38 states making medical cannabis available for those with...
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Cannabidiol for Scan-Related Anxiety in Women With Advanced Breast Cancer: A...
“Importance: Early evidence from studies outside of oncology has suggested that cannabidiol (CBD) may have anxiolytic effects without neuropsychiatric risks. An understanding of oral CBD in patients...
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Cannabinoid-Induced Immunogenic Cell Death of Colorectal Cancer Cells Through...
“Background: Our recent studies have identified a link between sphingolipid metabolites and the induction of a specialized form of regulated cell death termed immunogenic cell death (ICD). We have...
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Current and Potential Use of Biologically Active Compounds Derived from...
“Cannabis sativa L. contains numerous compounds with antioxidant and anti-inflammatory properties, including the flavonoids and the cannabinoids, particularly Δ-9-tetrahydrocannabinol (THC) and...
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Cannabidiol promotes apoptosis and downregulation of oncogenic factors
“Patients with high-grade serous carcinoma of tubo-ovarian origin (HGSC) often experience significant side effects related to their disease and treatments, such as pain, discomfort, nausea, and...
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Cannabidiol Suppresses Metastatic Castration-Resistant Prostate Cancer...
“Metastatic castration-resistant prostate cancer (mCRPC) is an aggressive phenotype of prostate cancer (PC). Tryptophan oxidative catabolism by indoleamine 2,3-dioxygenase-1 (IDO1) cleaves the indole...
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Tobacco and marijuana use and their association with serum prostate-specific...
“African American (AA) men experience more than twice the prostate cancer mortality as White men yet are under-represented in academic research involving prostate-specific antigen (PSA), a biomarker...
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The Anticancer Activity of Cannabinol (CBN) and Cannabigerol (CBG) on Acute...
“Several cannabis plant-derived compounds, especially cannabinoids, exhibit therapeutic potential in numerous diseases and conditions. In particular, THC and CBD impart palliative, antiemetic, as well...
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The Role of Cannabinoids and the Endocannabinoid System in the Treatment and...
“Despite using the recommended anti-emetic treatments, control of nausea and vomiting is still an unmet need for cancer patients undergoing chemotherapy treatment. Few properly controlled clinical...
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Lebanese Cannabis sativa L. extract protects from cisplatin-induced...
“Background: Cisplatin is an anti-cancer drug used to treat a plethora of solid tumors. However, it is associated with dose dependent nephrotoxicity limiting its use as anticancer agent. Objective:...
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Unveiling cellular changes in leukaemia cell lines after cannabidiol...
“The present study was aimed at revealing the metabolic changes that occurred in the cellular lipid pattern of acute and chronic myeloid leukaemia cells following treatment with cannabidiol (CBD). CBD...
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Cannabidiol suppresses proliferation and induces cell death, autophagy and...
“Background and aim: Cholangiocarcinoma (CCA) is usually diagnosed at a late stage, leading to treatment failure. Cannabidiol (CBD), exhibits diverse anti-cancer effects in various cancers, offering...
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Exploring the Therapeutic Potential of Cannabidiol in U87MG Cells: Effects on...
“Cannabinoids include both endogenous endocannabinoids and exogenous phytocannabinoids, such as cannabidiol (CBD), and have potential as therapeutic agents in cancer treatment due to their selective...
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Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating...
“Background: Doxorubicin (DOX) is a chemotherapeutic agent widely used for cancer treatment and has non-negligible cardiotoxicity. Some previous studies have reported that cannabidiol (CBD) has...
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GPR55 in the tumor microenvironment of pancreatic cancer controls tumorigenesis
“Background: The G protein-coupled receptor 55 (GPR55) is part of an expanded endocannabinoid system (ECS), and plays a pro-tumorigenic role in different cancer models, including pancreatic cancer....
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Cannabidiol attenuates lipid metabolism and induces CB1 receptor-mediated ER...
“Ovarian cancer (OC) is the most deadly gynecological tumor. OC cells utilize cellular metabolic reprogramming to gain a survival advantage, particularly through aberrant lipid metabolic process. As...
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