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The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?
“The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last decade. The immense data load published on its dual role in both tumorigenesis and inhibition of tumor growth...
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Chemotherapy-induced cachexia dysregulates hypothalamic and systemic...
“Muscle wasting, anorexia, and metabolic dysregulation are common side-effects of cytotoxic chemotherapy, having a dose-limiting effect on treatment efficacy, and compromising quality of life and...
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Using Cannabis to Treat Cancer-Related Pain.
“OBJECTIVE: To describe which cannabinoids and terpenes are effective for treating pain. CONCLUSION: Cannabis and cannabinoid medicines, as modulators of the endocannabinoid system, offer novel...
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Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in...
“Cannabidiol, a major non-psychotomimetic compound derived from Cannabis sativa, is a potential therapeutic agent for a variety of diseases such as inflammatory diseases, chronic neurodegenerative...
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Medical Cannabis Use in Glioma Patients Treated at a Comprehensive Cancer...
“Glioma is a devastating primary tumor of the central nervous system with difficult-to-manage symptoms. Cannabis products have been postulated to potentially benefit glioma patients. Recent state...
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Down-Regulation of Cannabinoid Type 1 (CB1) Receptor and its Downstream...
“Changes in the regulation of endocannabinoid production, together with an altered expression of their receptors are hallmarks of cancer, including colorectal cancer (CRC). Although several studies...
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Cannabinoids: Current and Future Options to Treat Chronic and...
“Increases in cancer diagnosis have tremendous negative impacts on patients and their families, and major societal and economic costs. The beneficial effect of chemotherapeutic agents on tumor...
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5-Chlorobenzofuran-2-carboxamides: From allosteric CB1 modulators to...
“Cannabinoids as THC and the CB1 allosteric modulator CBD were reported to have antiproliferative activities with no reports for other CB1 allosteric modulators as the 5-chloroindole-2-carboxamide...
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Modulation of the Endocannabinoid System as a Potential Anticancer Strategy.
“Currently, the involvement of the endocannabinoid system in cancer development and possible options for a cancer-regressive effect of cannabinoids are controversially discussed. In recent decades, a...
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Should Oncologists Recommend Cannabis?
“Cannabis is a useful botanical with a wide range of therapeutic potential. Global prohibition over the past century has impeded the ability to study the plant as medicine. However,...
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The oncogenic role of CB2 in the progression of non-small-cell lung cancer.
“Several studies have verified the important role of cannabinoid and cannabinoid receptor agonists in tumor progression. However, little is known about the precise role of CB2 expression level in the...
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Dramatic response to Laetrile and cannabidiol (CBD) oil in a patient with...
“Complimentary alternative medicine use is common in women with gynecologic cancers. Cannabinoid receptors are potential therapeutic targets in ovarian cancer. Communication with patients is critical...
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Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and...
“Although oxaliplatin is an effective chemotherapeutic drug for colorectal cancer (CRC) treatment, patients often develop resistance to it. Therefore, a new strategy for CRC treatment is needed. The...
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The Endocannabinoid System and its Modulation by Cannabidiol (CBD).
“The endocannabinoid system (ECS) is an extensive endogenous signaling system with multiple elements, the number of which may be increasing as scientists continue to elucidate its role in human...
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Antitumor Cannabinoid Chemotypes: Structural Insights.
“Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite, and pain. For this reason, cannabinoids have been successfully used in the treatment of some of the unwanted...
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The heterogeneity and complexity of Cannabis extracts as antitumor agents
“The Cannabis plant contains over 100 phytocannabinoids and hundreds of other components. The biological effects and interplay of these Cannabis compounds are not fully understood and yet influence...
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Isolation, Synthesis And Structure Determination Of Cannabidiol Derivatives...
“In a continuing effort to explore the structural diversity and pharmacological activities of natural products based scaffolds, herein, we report the isolation, synthesis, and structure determination...
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Strong reasons make strong actions: medical cannabis and cancer—a call for...
“Call it cannabis, not marijuana or weed. It has been more than 17 years since the Canadian prohibitory regulations on the use of medical cannabis began to ease and more than 17 weeks (more than 6...
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Cannabinoid Signaling in Cancer.
“The family of chemical structures that interact with a cannabinoid receptor are broadly termed cannabinoids. Traditionally known for their psychotropic effects and their use as palliative medicine in...
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Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric...
“The main chemical component of cannabis, cannabidiol (CBD), has been shown to have antitumor properties. The present study examined the in vitro effects of CBD on human gastric cancer SGC-7901...
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